Anti-Hu CD263 PE

Anti-Hu CD263 PE
Regulatory status
RUO
Antigen
CD263
Clone
TRAIL-R3-02
Format
PE
Reactivity
Human
Application
FC (QC tested)
Excitation laser
blue (488 nm)
Variant
0.1 mg
1P-518-C100
In stock
340.00 USD

0.025 mg
1P-518-C025
Ask for delivery term HERE
170.00 USD
Variant
0.1 mg
11-261-C100
In stock
340.00 USD

0.1 mg
11-261-C100
In stock
170.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG1
Specificity
The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Workshop
HLDA X
Application
FC (QC tested)
Application details
Flow cytometry: Recommended dilution: 1-6 μg/ml.
Reactivity
Human
Immunogen
TRAIL-R3 (aa 1-280) - hIgGhc fusion protein
Other names
TNFRSF10C, DcR1, TRAIL-R3, TRID, LIT
Concentration
0.1 mg/ml
Preparation
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Formulation
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Storage and handling
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
TNFRSF10C, DcR1, TRAIL-R3, TRID, LIT
Antigen description
TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).
Entrez Gene ID 8794
UniProt ID O14798
1P-518 FC
Separation of cells stained using anti-human 263 (TRAIL-R3-02) PE antibody (concentration in sample 5 μg/ml, red) from cells stained using mouse IgG1 isotype control (MOPC-21) PE antibody (concentration in sample 5 μg/ml, grey) in flow cytometry analysis (surface staining) of CD263 transfected HEK-293 cell suspension.

General references:

Deligezer U, Dalay N: Expression of the TRAIL Receptors in Blood Mononuclear Cells in Leukemia. Pathol Oncol Res. 2007;13(4):290-4.
PubMed
Falschlehner C, Emmerich CH, Gerlach B, Walczak H: TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol. 2007;39(7-8):1462-75.
PubMed
Mérino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O: Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol. 2006 Oct;26(19):7046-55.
PubMed
Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC Cancer. 2005 May 25;5(1):54.
PubMed
Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK: Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18099-104.
PubMed
Variant
0.1 mg
1P-518-C100
In stock
340.00 USD

0.025 mg
1P-518-C025
Ask for delivery term HERE
170.00 USD
Variant
0.1 mg
11-261-C100
In stock
340.00 USD

0.1 mg
11-261-C100
In stock
170.00 USD