Anti-Hu CD261 APC

Anti-Hu CD261 APC
Regulatory status
RUO
Antigen
CD261
Clone
DR-4-02
Format
APC
Reactivity
Human
Application
Excitation laser
red (633 nm)
Variant
0.1 mg
1A-403-C100
Ask for delivery term HERE
376.20 USD

0.025 mg
1A-403-C025
Delivery 1 week
188.10 USD
Variant
0.1 mg
1A-403-C100
Ask for delivery term HERE
376.20 USD

0.025 mg
1A-403-C025
Delivery 1 week
188.10 USD
Product details
Description
Images
References
SDS download
Isotype
Mouse IgG1
Specificity
The mouse monoclonal antibody DR-4-02 recognizes an extracellular epitope of TRAIL-R1 (DR4), a human death receptor 4 expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
Workshop
HLDA IX
Application
Application details
Flow cytometry: Recommended dilution: 2-4 μg/ml.
Reactivity
Human
Immunogen
Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
Concentration
0.1 mg/ml
Preparation
Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Formulation
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
DR4, APO2, TNFRSF10A, TRAILR1, TRAIL-R1
Antigen description
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
Entrez Gene ID 8797
UniProt ID O00220
1A-403 FC
Flow cytometry analysis (surface staining) of partially CD261-transfected HEK-293 cells with anti-CD261/TRAIL-R1 (DR-4-02) APC.

General references:

Corallini F, Milani D, Nicolin V, Secchiero P: TRAIL, caspases and maturation of normal and leukemic myeloid precursors. Leuk Lymphoma. 2006 Aug;47(8):1459-68.
PubMed

Product specific references:

Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis. 2008 Mar;13(3):423-36.
PubMed
Variant
0.1 mg
1A-403-C100
Ask for delivery term HERE
376.20 USD

0.025 mg
1A-403-C025
Delivery 1 week
188.10 USD
Variant
0.1 mg
1A-403-C100
Ask for delivery term HERE
376.20 USD

0.025 mg
1A-403-C025
Delivery 1 week
188.10 USD

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