Exbio — Research products — Antibodies — CD and related antigens — Anti-Hu CD231 Purified

Anti-Hu CD231 Purified

Regulatory status

RUO

Antigen

CD231

Clone

B2D

Format

Purified

Reactivity

Human

Application

IP, IHC, WB, FC (QC tested)

Variant

0.1 mg

11-200-C100

In stock

130.00 USD

Variant

0.1 mg

11-261-C100

In stock

130.00 USD

Contact distributor

Product details

Description

Images

References

Isotype

Mouse IgG1

Specificity

The mouse monoclonal antibody B2D recognizes an extracellular epitope of CD231 (TALLA-1, tetraspanin 7), a transmembrane glycoprotein expressed in neuronal tissue and T-ALL.

Application

IP, IHC, WB, FC (QC tested)

Application details

Immunohistochemistry: Positive control: brain.
Flow cytometry: Recommended dilution: 1-4 µg/ml

Reactivity

Human

Immunogen

Human T-ALL cell line THP-6

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

TSPAN7, TALLA-1, MXS1, MRX58, TM4SF2

Antigen description

CD231 (TALLA-1, T-ALL-asociated antigen 1), also known as tetraspanin 7, is a 150 kDa (under reducing conditions 32-45 kDa) transmembrane glycoprotein of tetraspanin family, expressed in T-type acute lymphoblastic leukemia, neuroblastoma, and neuronal tissue. Mutations of CD231 gene are associated with X-linked mental retardation, Huntington´s chorea, and myotonic dystrophy. CD231 interacts with integrins and may have a role in the control of neurite outgrowth. Antibodies to CD231 are important for detection of T-ALL and are potential targets of its treatment.

Entrez Gene ID 7102

UniProt ID P41732

Flow cytometry analysis (surface staining) of CD231 in JURKAT cells with anti-CD231 (B2D) purified, GAM-APC.

Product specific references:

Takagi S, Fujikawa K, Imai T, Fukuhara N, Fukudome K, Minegishi M, Tsuchiya S, Konno T, Hinuma Y, Yoshie O: Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily. Int J Cancer. 1995 May 29;61(5):706-15.
PubMed

Variant

0.1 mg

11-200-C100

In stock

130.00 USD

Variant

0.1 mg

11-261-C100

In stock

130.00 USD

Contact distributor

Datasheet download