Anti-Hu CD226 Purified

Anti-Hu CD226 Purified
Regulatory status
RUO
Antigen
CD226
Clone
11A8
Format
Purified
Reactivity
Non-human primates, Human
Application
Variant
0.1 mg
11-926-C100
In stock
140.00 USD
Variant
0.1 mg
11-926-C100
In stock
140.00 USD
Product details
Description
References
Isotype
Mouse IgG1 kappa
Specificity
The mouse monoclonal antibody 11A8 recognizes an extracellular epitope within CD226 transmembrane glycoprotein.
Application
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Non-human primates, Human
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
DNAM1, PTA1, TLiSA1
Antigen description
CD226 is a type I transmembrane glycoprotein, which is expressed after activation on NK cells, platelets, monocytes, and some T cells. Its expression is increased in patients suffering from some autoimmune diseases or viral infections. CD226 is being phosphorylated on its cytoplasmic tail and interacts with LFA-1 complex (CD11a/CD18), resulting in calcium-independent intercellular contacts. Ligands for CD226 are CD155 and CD112.
Entrez Gene ID 10666
UniProt ID Q15762

Product specific references:

Fourcade J, Sun Z, Chauvin JM, Ka M, Davar D, Pagliano O, Wang H, Saada S, Menna C, Amin R, Sander C, Kirkwood JM, Korman AJ, Zarour HM: CD226 opposes TIGIT to disrupt Tregs in melanoma. JCI Insight. 2018 Jul 26;3(14):e121157.
PubMed
Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M: Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol. 2004 Apr 1;172(7):3994-8.
PubMed
Deuss FA, Watson GM, Goodall KJ, Leece I, Chatterjee S, Fu Z, Thaysen-Andersen M, Andrews DM, Rossjohn J, Berry R: Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1. J Biol Chem. 2019 Aug 16;294(33):12534-12546.
PubMed
Deng C, Li W, Fei Y, Wang L, Chen Y, Zeng X, Zhang F, Li Y: Imbalance of the CD226/TIGIT immune checkpoint is involved in the pathogenesis of primary biliary cholangitis. Front Immunol. 2020 Jul 24;11:1619.
PubMed
Variant
0.1 mg
11-926-C100
In stock
140.00 USD
Variant
0.1 mg
11-926-C100
In stock
140.00 USD

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