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Exbio
—
Research products
—
Antibodies
—
CD and related antigens
—
Anti-Hu CD206 Purified Low Endotoxin
Anti-Hu CD206 Purified Low Endotoxin
Regulatory status
RUO
Antigen
CD206
Clone
15-2
Format
Purified Low Endotoxin
Reactivity
Human
Application
IP, WB, FC (QC tested), IHC(F), ICC, FUNC
Variant
0.1 mg
12-782-C100
In stock
130.00 USD
Variant
0.1 mg
12-782-C100
In stock
130.00 USD
Contact distributor
Product details
Description
Images
References
SDS download
Isotype
Mouse IgG1 kappa
Specificity
The mouse monoclonal antibody 15-2 (also known as MR15-2) recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes.
Workshop
HLDA VII: WS Code 70802
Application
IP, WB, FC (QC tested), IHC(F), ICC, FUNC
Application details
Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 µg/ml
Reactivity
Human
Immunogen
Purified human mannose receptor
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
MMR, MRC1, CLEC13DL
Antigen description
CD206 (macrophage mannose receptor, MMR), also known as mannose receptor C1 (MRC1), is a type I transmembrane glycoprotein serving as pattern recognition receptor for carbogydrate groups on the surface of bacteria, fungi and other pathogens. Expressed mainly on tissue macrophages and dendritic cells, CD206 mediates endocytosis of these pathogens and presentation of their antigens to the adaptive immune system. CD206 can also be detected in a soluble form in human plasma and is elevated in patients with acute sepsis.
Entrez Gene ID
4360
UniProt ID
P22897
Flow cytometry surface staining pattern of human stimulated (GM-CSF + IL-4) peripheral blood mononuclear cells stained using anti-human CD206 (15-2) purified antibody (low endotoxin, concentration in sample 9 μg/ml), GAM PE.
Separation of human CD206 positive dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red-filled) from non-stimulated lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human stimulated (GM-CSF + IL-4) peripheral blood mononuclear cells stained using anti-human CD206 (15-2) purified antibody (low endotoxin, concentration in sample 9 μg/ml), GAM PE.
Western blotting analysis of human CD206 using mouse monoclonal antibody 15-2 on lysates of differentiated monocytes (two batches), and on THP-1 and Raji cells (negative controls) under reducing and non-reducing conditions. Nitrocellulose membrane was probed with 2 µg/ml of mouse monoclonal antibody followed by IRDye800-conjugated anti-mouse secondary antibody. CD206 was detected around 170 kDa.
Product specific references:
Shan M, Klasse PJ, Banerjee K, Dey AK, Iyer SP, Dionisio R, Charles D, Campbell-Gardener L, Olson WC, Sanders RW, Moore JP: HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells. PLoS Pathog. 2007 Nov;3(11):e169.
PubMed
Quardokus EM, Saunders DC, McDonough E, Hickey JW, Werlein C, Surrette C, Rajbhandari P, Martinez Casals A, Tian H, Lowery L, Neumann EK, Björklund F, Neelakantan TV, Croteau J, Wiblin AE, Fisher J, Livengood AJ, Dowell KG, Silverstein JC, Spraggins JM, Pryhuber GS, Deutsch G, Ginty F, Nolan GP, Melov S, Jonigk D, Caldwell MA, Vlachos IS, Mueller W, Gehlenborg N, Stockwell BR, Lundberg E, Snyder MP, Germain RN, Camarillo JM, Kelleher NL, Börner K, Radtke AJ: Organ mapping antibody panels: a community resource for standardized multiplexed tissue imaging. Nat Methods 2023 Aug;20(8):1174-1178. doi: 10.1038/s41592-023-01846-7.
PubMed
Further SDS language mutations available for download below. Please contact us with request for additional languages on info@exbio.cz
MPAb_SDS_v1_GB.pdf
MPAb_SDS_v1_TR.pdf
MPAb_SDS_v6_CH.pdf
MPAb_SDS_v6_CS.pdf
MPAb_SDS_v6_EN.pdf
MPAb_SDS_v6_ES.pdf
MPAb_SDS_v6_FR.pdf
MPAb_SDS_v6_IT.pdf
MPAb_SDS_v6_NO.pdf
MPAb_SDS_v6_PL.pdf
MPAb_SDS_v6_PT.pdf
MPAb_SDS_v6_SE.pdf
MPAb_SDS_v6_SK.pdf
MPAb_SDS_v7_DE.pdf
Variant
0.1 mg
12-782-C100
In stock
130.00 USD
Variant
0.1 mg
12-782-C100
In stock
130.00 USD
Contact distributor
Datasheet download
Bulk requests
Technical support for this product
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