Anti-Hu CD155 PE

Anti-Hu CD155 PE
Regulatory status
RUO
Antigen
CD155
Clone
SKII.4
Format
PE
Reactivity
Human
Application
Excitation laser
blue (488 nm)
Variant
100 tests
1P-851-T100
In stock
220.00 USD
Variant
0.1 mg
11-261-C100
In stock
220.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG1
Specificity
The mouse monoclonal antibody SKII.4 recognizes an extracellular epitope of CD155, a transmembrane glycoprotein, known as poliovirus and cytomegalovirus receptor.
Application
Application details
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Reactivity
Human
Immunogen
human neuroblastoma SK-L cells
Preparation
Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Formulation
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
PVR, HVED, NECL5, PVS, TAGE4, CMVR
Antigen description
CD155 is a type I transmembrane glycoprotein of the nectin family, which serves as an adhesion molecule involved in intercellular and cell-extracellular matrix interactions. CD155 (nectin-like 5) heterodimerizes with CD113 (nectin-3) and this complex binds to CD51/CD61 complex (integrin alphaVbeta3), and to vitronectin. CD155 is also thought to regulate CD44 binding to hyaluronan, and serves as a receptor for poliovirus and cytomegalovirus. It is expressed on endothelial cells, epithelia, central nervous system, and monocytes.
Entrez Gene ID 5817
UniProt ID P15151
1P-851_FC_Profil značení
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD155 (SKII.4) PE antibody (10 μl reagent / 100 μl of peripheral whole blood).
1P-851_FC_Histogram
Separation of human CD155 positive monocytes (red-filled) from lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD155 (SKII.4) PE antibody (10 μl reagent / 100 μl of peripheral whole blood).

Product specific references:

Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M: A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. Eur J Immunol. 2009 Mar;39(3):695-703.
PubMed
Jin HS, Choi DS, Ko M, Kim D, Lee DH, Lee S, Lee AY, Kang SG, Kim SH, Jung Y, Jeong Y, Chung JJ, Park Y: Extracellular pH modulating injectable gel for enhancing immune checkpoint inhibitor therapy. J Control Release. 2019 Oct 25;315:65-75.
PubMed
Fionda C, Abruzzese MP, Zingoni A, Soriani A, Ricci B, Molfetta R, Paolini R, Santoni A, Cippitelli M: Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation. BMC Cancer. 2015 Jan 22;15:17.
PubMed
Davis ZB, Sowrirajan B, Cogswell A, Ward JP, Planelles V, Barker E: CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells. AIDS Res Hum Retroviruses. 2017 Feb;33(2):93-100.
PubMed
Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA: The TIGIT/CD226 axis regulates human T cell function. J Immunol. 2012 Apr 15;188(8):3869-75
PubMed
Josefsson SE, Beiske K, Blaker YN, Førsund MS, Holte H, Østenstad B, Kimby E, Köksal H, Wälchli S, Bai B, Smeland EB, Levy R, Kolstad A, Huse K, Myklebust JH: TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma. Cancer Immunol Res. 2019 Mar;7(3):355-362.
PubMed
Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M: Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J Immunol. 2004 Apr 1;172(7):3994-8.
PubMed
Variant
100 tests
1P-851-T100
In stock
220.00 USD
Variant
0.1 mg
11-261-C100
In stock
220.00 USD

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