Anti-Hu CD132 Purified

Anti-Hu CD132 Purified
Regulatory status
RUO
Antigen
CD132
Clone
TUGh4
Format
Purified
Reactivity
Human, Dog
Application
Variant
0.1 mg
11-194-C100
Ask for delivery term HERE
143.00 USD

0.025 mg
11-194-C025
Delivery 1 week
71.50 USD
Variant
0.1 mg
11-194-C100
Ask for delivery term HERE
143.00 USD

0.025 mg
11-194-C025
Delivery 1 week
71.50 USD
Product details
Description
Images
References
SDS download
Isotype
Rat IgG2b kappa
Specificity
The rat monoclonal antibody TUGh4 recognizes an extracellular epitope of CD132 (the common gamma chain), a 65-70 kDa type I transmembrane glycoprotein broadly expressed by most leukocytes.
Workshop
HLDA VI: WS Code C-89
Application
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Human, Dog
Immunogen
Human CD132-transfected cell line
Concentration
1 mg/ml
Preparation
Purified by protein-G affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
common gamma chain, IL2RG, SCIDX, IMD4
Antigen description
CD132 / common gamma chain is an essential component of receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, and it is critical for development of the immune system. Its mutation causes X-linked severe combined immunodeficiency disease (XSCID). CD132 is expressed on lymphocytes, NK cells, monocytes, and granulocytes. Through its cytoplasmic part which containsfour tyrosines and an SH2 domain, CD132 transcuces signal to downstream JAK/STAT pathway.
Entrez Gene ID 3561
UniProt ID P31785
11-194_FC_Profil Značení
Flow cytometry surface staining pattern of human peripheral blood stained using anti-human CD132 (TUGh4) purified antibody (concentration in sample 4 μg/ml) GAM APC.
11-194_FC_Histogram
Separation of human lymphocytes (red-filled) from human CD132 negative blood debris (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD132 (TUGh4) purified antibody (concentration in sample 4 μg/ml) GAM APC.

Product specific references:

Corrigall VM, Arastu M, Khan S, Shah C, Fife M, Smeets T, Tak PP, Panayi GS: Functional IL-2 receptor beta (CD122) and gamma (CD132) chains are expressed by fibroblast-like synoviocytes: activation by IL-2 stimulates monocyte chemoattractant protein-1 production. J Immunol. 2001 Mar 15;166(6):4141-7.
PubMed
Brisslert M, Bokarewa M, Larsson P, Wing K, Collins LV, Tarkowski A: Phenotypic and functional characterization of human CD25+ B cells. Immunology. 2006 Apr;117(4):548-57.
PubMed
Amu S, Brisslert M: Phenotype and function of CD25-expressing B lymphocytes isolated from human umbilical cord blood. Clin Dev Immunol. 2011;2011:481948.
PubMed
Fiorito S, Magrini L, Adrey J, Mailhé D, Brouty-Boyé D: Inflammatory status and cartilage regenerative potential of synovial fibroblasts from patients with osteoarthritis and chondropathy. Rheumatology (Oxford). 2005 Feb;44(2):164-71.
PubMed
Marino JH, Tan C, Taylor AA, Bentley C, Van De Wiele CJ, Ranne R, Paliotta M, Broughan TA, Teague TK: Differential IL-7 responses in developing human thymocytes. Hum Immunol. 2010 Apr;71(4):329-33.
PubMed
Itano M, Tsuchiya S, Morita S, Fujie H, Ishii N, Yanagisawa T, Ohashi Y, Minegishi M, Sugamura K, Konno T: IL-2 receptor gamma chain expression on CD34 positive hematopoietic progenitor cells from bone marrow and cord blood. Tohoku J Exp Med. 1996 Apr;178(4):389-98.
PubMed
Variant
0.1 mg
11-194-C100
Ask for delivery term HERE
143.00 USD

0.025 mg
11-194-C025
Delivery 1 week
71.50 USD
Variant
0.1 mg
11-194-C100
Ask for delivery term HERE
143.00 USD

0.025 mg
11-194-C025
Delivery 1 week
71.50 USD

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