Exbio — Research products — Antibodies — CD and related antigens — Anti-Hu CD129 Purified Low Endotoxin

Anti-Hu CD129 Purified Low Endotoxin

Regulatory status

RUO

Antigen

CD129

Clone

AH9R7

Format

Purified Low Endotoxin

Reactivity

Human

Application

ELISA, FC (QC tested), FUNC

Variant

0.1 mg

12-788-C100

In stock

143.00 USD

Variant

0.1 mg

12-788-C100

In stock

143.00 USD

Contact distributor

Product details

Description

References

SDS download

Isotype

Mouse IgG2b kappa

Specificity

The mouse monoclonal antibody AH9R7 recognizes an extracellular epitope of CD129 / IL-9R alpha, a 57 kDa type I transmembrane glycoprotein expressed at low levels by lymphocytes, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons.

Application

ELISA, FC (QC tested), FUNC

Application details

Functional application: Blocking.
Flow cytometry: It is recommended to use bright fluorochromes or signal multiplying detection.

Reactivity

Human

Immunogen

Human CD129-transfected cell line

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

IL9R

Antigen description

CD129 serves as the high affinity alpha subunit of IL-9 receptor. It associates with CD132, the common gamma chain shared by receptors of many different cytokines. CD129 is expressed at low levels by T and B cells, blood cell progenitors, eosinophils, mast cells, epithelial cells, muscle cells and neurons. Its signaling (through JAK/STAT pathways) results in proliferative and anti-apoptotic response, which is critical e.g. for intrathymic T cell development and survival of various cell types. The gene for CD129 is located at the pseudoautosomal regions of X and Y chromosomes and it may be related with the development of asthma.

Entrez Gene ID 3581

UniProt ID Q01113

Product specific references:

De Smedt M, Verhasselt B, Kerre T, Vanhecke D, Naessens E, Leclercq G, Renauld JC, Van Snick J, Plum J: Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development. J Immunol. 2000 Feb 15;164(4):1761-7.
PubMed

Grasso L, Huang M, Sullivan CD, Messler CJ, Kiser MB, Dragwa CR, Holroyd KJ, Renauld JC, Levitt RC, Nicolaides NC: Molecular analysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells. Identification of a splice variant encoding for a nonfunctional cell surface receptor. J Biol Chem. 1998 Sep 11;273(37):24016-24.
PubMed

Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y: IL-9 inhibits oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated human monocytes through TGF-beta. J Immunol. 2002 Apr 15;168(8):4103-11.
PubMed

Pilette C, Ouadrhiri Y, Van Snick J, Renauld JC, Staquet P, Vaerman JP, Sibille Y: Oxidative burst in lipopolysaccharide-activated human alveolar macrophages is inhibited by interleukin-9. Eur Respir J. 2002 Nov;20(5):1198-205.
PubMed