Anti-Hu CD119 Purified

Anti-Hu CD119 Purified
Regulatory status
RUO
Antigen
CD119
Clone
GIR-208
Format
Purified
Reactivity
Human
Variant
0.1 mg
11-875-C100
In stock
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG1
Specificity
The mouse monoclonal antibody GIR-208 recognizes an epitope within extracellular part of CD119, a transmembrane glycoprotein of cytokine receptor family.
Workshop
HLDA X
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Human
Immunogen
CD119 purified from human placenta
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
IFNGR1, IFNgammaRa, IMD27
Antigen description
CD119 (alpha subunit of interferon gamma receptor) is a type I transmembrane glycoprotein, which associates with IFNgammaAF1 to form functional receptor for interferon gamma, although CD119 alone is able to bind the cytokin. It is expressed on monocytes, macrophages, lymphocytes, NK cells, neutrophils, fibroblasts, epithelial and endothelial cells, as well as in many tumours.
Entrez Gene ID 3459
UniProt ID P15260
11-875_FC_Profil značení
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD119 (GIR-208) purified antibody (concentration in sample 0,6 μg/ml, GAM APC).
11-875_FC_Histogram
Separation of monocytes stained anti-human CD119 (GIR-208) purified antibody (concentration in sample 0,6 μg/ml, GAM APC, red-filled) from monocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).

Product specific references:

Fujii K, Miyahara Y, Harada N, Muraoka D, Komura M, Yamaguchi R, Yagita H, Nakamura J, Sugino S, Okumura S, Imoto S, Miyano S, Shiku H: Identification of an immunogenic neo-epitope encoded by murine sarcoma using CXCR3 ligand mRNAs as sensors. Oncoimmunology. 2017 Mar 20;6(5):e1306617.
PubMed
Alavi S, Stewart AJ, Kefford RF, Lim SY, Shklovskaya E, Rizos H: Interferon signaling is frequently downregulated in melanoma. Front Immunol. 2018 Jun 21;9:1414.
PubMed
Crescioli C, Cosmi L, Borgogni E, Santarlasci V, Gelmini S, Sottili M, Sarchielli E, Mazzinghi B, Francalanci M, Pezzatini A, Perigli G, Vannelli GB, Annunziato F, Serio M: Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes. Endocrinol. 2007 Oct;195(1):145-55.
PubMed
Igarashi T, Teramoto K, Ishida M, Hanaoka J, Daigo Y: The mechanism of de novo expression of programmed cell death-ligand 1 in squamous cell carcinoma of the lung. Oncol Rep. 2017 Oct;38(4):2189-2196.
PubMed
Hoh A, Heeg M, Ni Y, Schuch A, Binder B, Hennecke N, Blum HE, Nassal M, Protzer U, Hofmann M, Urban S, Thimme R: Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro. J Virol. 2015 Jul;89(14):7433-8.
PubMed
El Darzi E, Bazzi S, Daoud S, Echtay KS, Bahr GM: Differential regulation of surface receptor expression, proliferation, and apoptosis in HaCaT cells stimulated with interferon-γ, interleukin-4, tumor necrosis factor-α, or muramyl dipeptide. Int J Immunopathol Pharmacol. 2017 Jun;30(2):130-145.
PubMed
Variant
0.1 mg
11-875-C100
In stock
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD