Exbio — Research products — Antibodies — CD and related antigens — Anti-Hu CD102 Purified

Anti-Hu CD102 Purified

Regulatory status

RUO

Antigen

CD102

Clone

CBR-IC2/2

Format

Purified

Reactivity

Human

Application

IP, FC (QC tested), IHC(F)

Variant

0.1 mg

11-148-C100

In stock

143.00 USD

0.025 mg

11-148-C025

Delivery 1 week

71.50 USD

Variant

0.1 mg

11-148-C100

In stock

143.00 USD

0.025 mg

11-148-C025

Delivery 1 week

71.50 USD

Contact distributor

Product details

Description

Images

References

SDS download

Isotype

Mouse IgG2a

Specificity

The mouse monoclonal antibody CBR-IC2/2 recognizes an extracellular epitope of CD102 (ICAM-2), an approximately 55 kDa type I transmembrane glycoprotein expressed mainly on vascular endothelial cells and folicular dendritic cells, in lower amount on lymphocytes, monocytes and platelets.

Workshop

HLDA V: WS Code BP363

Application

IP, FC (QC tested), IHC(F)

Application details

Flow cytometry: Recommended dilution: 2-4 μg/ml.

Reactivity

Human

Immunogen

Human CD102 cDNA transfected COS cells

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

ICAM2

Antigen description

CD102 / ICAM-2 (intracellular cell adhesion molecule-2), a counter receptor of LFA-1 (CD11a/CD18), is a transmembrane glycoprotein with two extracellular IgC-like domains and intracellular C-terminal tail. It is involved in lymphocyte recirculation and homing to the sites of inflammation. Through interaction with integrins it provides to the immune cells costimulatory signals. Expression of CD102 on blood cells (lymphocytes, monocytes, thrombocytes) is lower than on endothelium and follicular dendritic cells. CD102 levels are upregulated in lymph nodes with malignant infiltration.

Entrez Gene ID 3384

UniProt ID P13598

Flow cytometry analysis (surface staining) of human peripheral blood with anti-human CD102 (CBR-IC2/2) purified, GAM-APC.

Product specific references:

Juan M, Mullol J, Roca-Ferrer J, Fuentes M, Pérez M, Vilardell C, Yagüe J, Picado C: Regulation of ICAM-3 and other adhesion molecule expressions on eosinophils in vitro. Effects of dexamethasone. Allergy. 1999 Dec;54(12):1293-8.
PubMed

de Fougerolles AR, Springer TA: Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. J Exp Med. 1992 Jan 1;175(1):185-90.
PubMed

de Fougerolles AR, Stacker SA, Schwarting R, Springer TA: Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. J Exp Med. 1991 Jul 1;174(1):253-67.
PubMed

Kawamata N, Xu B, Nishijima H, Aoyama K, Kusumoto M, Takeuchi T, Tei C, Michie SA, Matsuyama T: Expression of endothelia and lymphocyte adhesion molecules in bronchus-associated lymphoid tissue (BALT) in adult human lung. Respir Res. 2009 Oct 22;10:97. doi: 10.1186/1465-9921-10-97.
PubMed

Maki G, Krystal G, Dougherty G, Takei F, Klingemann HG: Induction of sensitivity to NK-mediated cytotoxicity by TNF-alpha treatment: possible role of ICAM-3 and CD44. Leukemia. 1998 Oct;12(10):1565-72.
PubMed

Diacovo TG, deFougerolles AR, Bainton DF, Springer TA: A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2. J Clin Invest. 1994 Sep;94(3):1243-51.
PubMed