Anti-GABA(B) R2 Purified

Anti-GABA(B) R2 Purified
Regulatory status
RUO
Antigen
GABA(B) R2
Clone
PAb (551)
Format
Purified
Reactivity
Rat, Mouse
Application
WB, ICC
Variant
0.1 mg
11-551-C100
In stock
Variant
0.1 mg
11-261-C100
In stock
Product details
Images
References
Isotype
Rabbit polyclonal
Specificity
The polyclonal antibody recognizes C-terminus of gamma-aminobutyric acid (GABA) B receptor 2 (recognized epitope: the last 23 aa). GB2 apparent MW ~120 kDa.
Application
WB, ICC
Reactivity
Rat, Mouse
Immunogen
Synthetic peptide (coupled with THG) derived from the last 23 aa of mouse GABA B receptor 2. 100% homology with human GB2.
Other names
GABABR2, GABBR2
Concentration
1 mg/ml
Preparation
Purified from rabbit serum by affinity chromatography
Formulation
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Exbio licence note
Unless indicated otherwise, all products are For Research Use Only and not for diagnostic use. In vivo diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s. © 2019 EXBIO Praha, a.s. All rights reserved.
11-551 WB
Western blotting analysis of GABA B receptor GB2 subunit in rat liver (1), GB2-transfected HEK292 cells (2) and rat brain (3) with polyclonal anti-GB2 antibody.

General references:

Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, Bettler B, Prézeau L, Pin JP: Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J. 2001 May 1;20(9):2152-9.
PubMed
Margeta-Mitrovic M, Jan YN, Jan LY: Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14643-8.
PubMed
Margeta-Mitrovic M, Jan YN, Jan LY: Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14649-54.
PubMed
Kniazeff J, Galvez T, Labesse G, Pin JP: No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits. J Neurosci. 2002 Sep 1;22(17):7352-61.
PubMed
Fritschy JM, Meskenaite V, Weinmann O, Honer M, Benke D, Mohler H: GABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization. Eur J Neurosci. 1999 Mar;11(3):761-8.
PubMed
Variant
0.1 mg
11-551-C100
In stock
Variant
0.1 mg
11-261-C100
In stock