Anti-DLL4 PE

Anti-DLL4 PE
Regulatory status
RUO
Antigen
DLL4
Clone
MHD4-46
Format
PE
Reactivity
Human
Application
FC (QC tested)
Excitation laser
blue (488 nm)
Variant
0.1 mg
1P-717-C100
In stock
220.00 USD
Variant
0.1 mg
11-261-C100
In stock
220.00 USD
Product details
Images
References
Isotype
Mouse IgG1 kappa
Specificity
The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
Application
FC (QC tested)
Reactivity
Human
Immunogen
recombinant soluble human DLL4
Other names
Delta like ligand 4, AOS6, canonical Notch ligand 4
Concentration
0.1 mg/ml
Preparation
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Formulation
Stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide
Storage and handling
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
1P-717_FC_Histogram
Separation of CHO/DLL4 cells stained using anti-human DLL4 (MHD4-46) PE antibody (10 μl reagent per million cells in 100 μl of cell suspension, red-filled) from CHO/DLL4 cells stained using mouse IgG1 isotype control (MOPC-21) PE antibody (concentration in sample 1 μg/ml, same as CD135 APC concentration, black-dashed) in flow cytometry analysis (surface staining) of CHO/DLL4 cell suspension.

Product specific references:

Yamanda S, Ebihara S, Asada M, Okazaki T, Niu K, Ebihara T, Koyanagi A, Yamaguchi N, Yagita H, Arai H: Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade. Blood. 2009 Apr 9;113(15):3631-9
PubMed
Oishi H, Sunamura M, Egawa S, Motoi F, Unno M, Furukawa T, Habib NA, Yagita H: Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer. Pancreas. 2010 Aug;39(6):897-903
PubMed
Sekine C, Koyanagi A, Koyama N, Hozumi K, Chiba S, Yagita H: Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes. Arthritis Res Ther. 2012 Mar 5;14(2):R45.
PubMed
Variant
0.1 mg
1P-717-C100
In stock
220.00 USD
Variant
0.1 mg
11-261-C100
In stock
220.00 USD