Anti-CD49f Purified

Anti-CD49f Purified
Regulatory status
RUO
Antigen
CD49f
Clone
GoH3
Format
Purified
Reactivity
Non-human primates, Horse, Pig, Rabbit, Cow, Dog, Cat, Human, Sheep, Mouse
Variant
0.1 mg
11-913-C100
In stock
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD
Product details
Description
Images
References
Isotype
Rat IgG2a
Specificity
The rat monoclonal antibody GoH3 recognizes an extracellular epitope of CD49f, an alpha6 integrin subunit.
Workshop
HCDM workshop listed
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Non-human primates, Horse, Pig, Rabbit, Cow, Dog, Cat, Human, Sheep, Mouse
Immunogen
mouse mammary tumor cells
Concentration
1 mg/ml
Preparation
Purified by protein-G affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
ITGA6, VLA6alpha, platelet gpIc, integrin subunit alpha 6
Antigen description
CD49f (alpha 6 integrin) is a type I transmembrane glycoprotein, which noncovalently associates with CD29 (beta 1 integrin) to form VLA-6, and with CD104 (beta 4 integrin) to form alpha6/beta4 integrin complex. CD49f is expressed on platelets, megakaryocytes, monocytes, T cells and thymocytes. It is widely expressed on many cultured adherent cell lines and on epithelia in non-lymphoid tissues. It is important for adhesion to laminins, invasin, and merosin, hence also for cell migration, embryogenesis, metastasis, formation of hemidesmosomes in epithelia, and other processes.
Entrez Gene ID 3655
UniProt ID P23229
11-913_FC_Profil značení
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD49f (GoH3) purified antibody (concentration in sample 1,7 μg/ml, GAM APC).
11-913_FC_Histogram
Separation of human blood thrombocytes stained using anti-CD49f (GoH3) purified antibody (concentration in sample 1,7 μg/ml, GAM APC, red-filled) from blood thromobocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).

Product specific references:

Martignani E, Ala U, Sheehy PA, Thomson PC, Baratta M: Whole transcriptome analysis of bovine mammary progenitor cells by P-Cadherin enrichment as a marker in the mammary cell hierarchy. Comparative Study Sci Rep. 2020 Aug 25;10(1):14183.
PubMed
Knapp DJ, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C, Eaves CJ: Distinct signaling programs control human hematopoietic stem cell survival and proliferation. Blood 2017 Jan 19;129(3):307-318
PubMed
Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, van Boxtel R, Wongvipat J, Dowling CM, Gao D, Begthel H, Sachs N, Vries RGJ, Cuppen E, Chen Y, Sawyers CL, Clevers HC: Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell 2014 Sep 25;159(1):163-175.
PubMed
Ikeda A, Yamamoto T, Mineshiba J, Takashiba S: Follistatin expressed in mechanically-damaged salivary glands of male mice induces proliferation of CD49f + cells. Sci Rep. 2020 Nov 17;10(1):19959.
PubMed
Variant
0.1 mg
11-913-C100
In stock
140.00 USD
Variant
0.1 mg
11-261-C100
In stock
140.00 USD

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