Anti-Bov CD45R Purified

Anti-Bov CD45R Purified
Regulatory status
RUO
Antigen
CD45R
Clone
IVA103
Format
Purified
Reactivity
Cow
Application
Variant
0.1 mg
11-352-C100
In stock
130.00 USD
Variant
0.1 mg
11-261-C100
In stock
130.00 USD
Product details
Description
Images
References
Isotype
Mouse IgG1
Specificity
The antibody IVA103 reacts with an extracellular epitope of CD45R antigen (bovine), a single chain type I transmembrane glycoprotein (member of the protein tyrosine phosphatase family), a restricted form of the CD45 family. CD45R is an essential regulator of T and B lymphocytes antigen receptor signaling and it is specifically expressed in hematopoietic cells.
Application
Application details
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Reactivity
Cow
Immunogen
Bovine leukocytes.
Concentration
1 mg/ml
Preparation
Purified by protein-A affinity chromatography.
Formulation
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage and handling
Store at 2-8°C. Do not freeze.
Exbio licence note
The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.
Other names
PTPRCR, T200R
Antigen description
CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.
11-352_ICC
Immunocytochemistry staining of acetone/methanol fixed bovine peripheral blood (lymphocyte-enriched suspension) using anti-bovine CD45R (IVA103); secondary antibody conjugated to FITC (green), DNA stained with DAPI (blue).
11-352_FC_Histogram
Separation of bovine CD45R positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of bovine peripheral whole blood stained using anti-bovine CD45R (IVA103) purified antibody (concentration in sample 0,1 μg/ml) GAM APC.
11-352_FC_Profil Značení
Flow cytometry surface staining pattern of bovine peripheral whole blood stained using anti-bovine CD45R (IVA103) purified antibody (concentration in sample 0,1 μg/ml) GAM APC.

Product specific references:

Naessens J, Howard CJ, Hopkins J: Nomenclature and characterization of leukocyte differentiation antigens in ruminants. Immunol Today. 1997 Aug;18(8):365-8.
PubMed
Naessens J & Hopkins J: Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995. Vet Immunol Immunopathol 52:213-468 (1996).
PubMed
Sopp P, Howard CJ: Investigation of PC36 (BoCD45R). Vet Immunol Immunopathol. 1996 Aug;52(4):271-4.
PubMed
Variant
0.1 mg
11-352-C100
In stock
130.00 USD
Variant
0.1 mg
11-261-C100
In stock
130.00 USD

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