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"I have been interested in priming of immature neonatal immune since my master study. During development of newborn´s immune system, both effector and immunoregulatory responses have to be set. This led me to focus on T regulatory cells (Tregs)."

Jiri Hrdy, Ph.D.
Head of immunology at Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.

Easy way how to identify regulatory T cells (Tregs) in human peripheral blood or umbilical cord blood.

Recombinant allergens are produced both in prokaryotic (mainly E. coli) and in eukaryotic (yeast and insect cells) expression systems and in addition to their use in diagnostics find their way also into immunotherapy of various allergies.

Further investigation of microtubular system, namely full understanding its assembly, dynamics and regulation, is an incentive goal both for clinical and basic researchers.

Higher expression of RPSA is characteristic for many carcinomas, and correlates with their invasivity and metastatic potential.

The mouse monoclonal antibody JOVI.1, recognizing an extracellular epitope on TCR Cbeta1 (TRBC1), is suitable for flow cytometry, immunoprecipitation, and immunohistochemistry (frozen sections). It is popular as a tool for analysis of T cell-mediated diseases.

We are proud to inform you that in March 2020 in Cytometry B (Clinical cytometry) a paper was released having one of our colleagues from EXBIO Praha team Miro Benko (Director, Product Development Department) as a co-author.

Recently developed strategy for prevention of cancer relapse due to acquired radioresistance may be based on immunotherapies. One promising approach is based on genetically modified T cells expressing chimeric antigen receptors (CAR).

New challengies in the diagnostics of allergies

Intended use: Development of qualitative and quantitative allergy tests and assays for assesment of patients reactivity profiles or follow up of allergic patients during immunotherapy.

In addition to ACE2 and TMPRSS2, also other host cell surface proteins may be involved in the interactions with the SARS-CoV-2 virus. It has been known since 2005 that broadly expressed transmembrane glycoprotein of the immunoglobulin superfamily CD147 (also known as basigin or EMMPRIN) facilitates SARS-CoV invasion for host cells.
 
Here we present a short communication of Prof. Vaclav Horejsi, PhD (IMG AS CR) on this Hot Topic.

While the COVID-19 pandemic rises exponentially influencing daily life of all of us, EXBIO decided to face the situation and focus all our effort on development of two Dry Reagent kits for cytometric analysis of T and B cell populations. Our goal was to provide all laboratories  with an efficient, reliable and fast tool for analyzing carefully selected cellular subpopulations important for characterizing the patient's samples. 

EXBIO is proud to inform you, that recently a paper with title: "High-sensitivity 5-, 6-, and 7-color PNH WBC assays for both Canto II and Navios platforms." was published in Cytometry B.

One of authors of this paper is EXBIO Flow Cytometry Expert Miro Benko.