OX-119 is a mouse monoclonal antibody, which recognizes an extracellular epitope of CD172g. This antibody is suitable for flow cytometry, and immunoprecipitation. CD172g is a transmembrane glycoprotein, which may play a role in inter-T cellular signaling by binding CD47, and thus in influencing T cell behaviour. CD172g is expressed on mature thymocytes, CD4+ T cells, CD8+ T cells, NK cells, and some B cells. It is absent on myeloid cells. Engagement of CD172g by CD47 expressed on antigen presenting cells results in enhanced antigen-specific T cell proliferation and costimulates T cell activation.
Anti-Hu CD172g Purified
Fig. 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD172g (OX-119) purified antibody (concentration in the sample 1.7 μg/ml, GAM APC).
YOL1/34 is a rat monoclonal antibody, which recognizes an epitope of alpha-tubulin in multiple species, especially in fixed state. This antibody is suitable for flow cytometry, Western blotting, immunohistochemistry, immunocytochemistry, and ELISA. The alpha-tubulin (relative molecular weight around 50 kDa) is a globular protein that exists in cells as part of soluble alpha/beta-tubulin dimer or is polymerized into microtubules. Microtubules are required for vital processes in eukaryotic cells including mitosis, meiosis, maintenance of cell shape and intracellular transport. They are also necessary for movement of cells by means of flagella and cilia.
FIG. 2: Immunocytochemistry staining of alpha-tubulin in K562 cells using purified rat monoclonal antibody YOL1/34 (concentration in the sample 6 μg/ml, DAR FITC, left picture) vs. Hoechst 34580 nuclear staining (right picture).
IG191E/A8 is a mouse monoclonal antibody, which recognizes mouse and human BCL6. This antibody is suitable for flow cytometry, immunoprecipitation, Western blotting, and immunohistochemistry. BCL6 is a zinc finger-containing transcription factor, which acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. On B cells, BCL6 induces proliferation, antibody class switching and affinity maturation, whereas it inhibits their differentiation into plasma cells. On T cells, BCL6 induces their differentiation into T-FH cells.
FIG.3: Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human BCL6 (IG191E/A8) purified antibody (concentration in the sample 5 μg/ml, GAM APC).
European Commission extended deadlines for the implementation of the new IVDR (Regulation No. 2017/746) in order to avoid disruption of the supply of in vitro medical devices.
Accordingly to most recent studies, SCIMP appears to be a key, well defined component in initiation TLR-mediated pro-inflammatory responses in macrophages.
Today we introduce four mouse monoclonal antibody clones, that have been added to our portfolio: Anti-human TROP2 (clone TrMab-6), anti-human TCR gamma/delta (clone 11F2), anti-human CD272 (MIH26), anti-human granzyme A (CB9).