Four new antibody clones in our portfolio

TS2/7 is a mouse monoclonal antibody, which recognizes an extracellular epitope of human CD49a. This antibody is suitable for flow cytometry, immunoprecipitation, and immunohistochemistry (frozen sections).

CD49a is the alpha 1 chain of VLA integrin complex (together with CD29, serving as the beta 1 chain), and is expressed on activated T cells, monocytes, NK cells, cultured neuronal cells, melanoma cells, mesenchymal cells (including smooth muscle cells), fibroblasts, hepatocytes, and microvascular endothelium. It binds to collagen IV and laminin 1. It is important for leukocyte migration into tissues. It is upregulated in inflammatory tissues, such as inflammed intestine.

Currently available formats:

Anti-Hu CD49a Purified

Coming soon:

Anti-Hu CD49a PE - Cat. No: 1P-873-T100

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Fig.1: Separation of HeLa cells stained using anti-CD49a (TS2/7) purified antibody (concentration in sample 0.6 μg/ml, GAM APC, red-filled) from HeLa cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).


 

E3 is a mouse monoclonal antibody, which recognizes an extracellular epitope on human CD307a, and is suitable for flow cytometry.

CD307a is a type I transmembrane glycoprotein of the Fc receptor family. It contains two ITAM motifs in its cytoplasmic domain. CD307a is expressed mainly on the surface of mature B-cells, and is down-regulated in germinal center B-cells. Expression of CD307a is higher in patients with autoimmune diseases, compared with healthy controls.

Currently available formats:

Anti-Hu CD307a Purified

Coming soon:

Anti-Hu CD307a PE - Cat. No.: 1P-860-T100

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Fig. 2: Flow cytometry multicolor surface staining of human lymphocytes stained using anti-human CD19 (LT19) APC antibody (10 μl reagent / 100 μl of peripheral whole blood) and anti-human CD307a (E3) purified antibody (5 μg/ml, GAM-FITC).


 

H5 is a mouse monoclonal antibody, which recognizes an extracellular epitope on human CD307c, and is suitable for flow cytometry.

CD307c is a type I transmembrane glycoprotein of the Fc receptor family. It contains both ITAM and ITIM motifs in its cytoplasmic domain. CD307c is expressed on the surface of NK cells, and T, Treg, B and plasma cell subsets. It seems to play a role in the regulation of immune response. Defects in CD307c function can result in autoimmune diseases, e.g. rheumatoid arthritis or systemic lupus erythematosus.

Currently available formats:

Anti-Hu CD307c Purified

Coming soon:

Anti-Hu CD307c PE - Cat. No.: 1P-858-T100

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Fig. 3: Flow cytometry multicolor surface staining of human lymphocytes stained using anti-human CD19 (LT19) APC antibody (10 μl reagent / 100 μl of peripheral whole blood) and anti-human CD307c (H5) purified antibody (1.7 μg/ml, GAM-FITC).


 

A1 is a mouse monoclonal antibody, which recognizes an extracellular epitope on human CD307d, and is suitable for flow cytometry.

CD307d is a type I transmembrane glycoprotein of the Fc receptor family. It contains two ITIM motifs and one ITSM motif in its cytoplasmic domain. CD307d is expressed mainly on the surface of memory B cells in mucosa-associated lymphoid tissues. It binds to aggregated immunoglobulin molecules (IgA, IgG). Defects of CD307d may play a role in HIV-induced memory B cell dysfunction.

Currently available formats:

Anti-Hu CD307d Purified
Anti-Hu CD307d PE

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Fig.4: Flow cytometry multicolor surface staining of human lymphocytes stained using anti-human CD19 (LT19) PE antibody (20 μl reagent / 100 μl of peripheral whole blood) and anti-human CD307d (A1) purified antibody (15 μg/ml, GAM-APC).

 

Would you like to have our antibodies in other formates? Let us know!

Contact: info@exbio.cz