The α/ß T- cell receptor (TCR) is a transmembrane heterodimer expressed on >90 % normal T-cells and T-cell lymphomas.
The extracellular part of both α and ß chains comprises constant (C) and variable (V) regions.
The ß constant region contains 2 functionally identical but mutually exclusive isoforms: TRBC1 and TRBC2.
Normal T cells usually represent a mixture of TRBC1+ and TRBC2+ cells, while clonal T-cell population contains either TRBC1+ or TRBC2+ cells.
The monoclonal antibody JOVI.1 recognizes the TRBC1+ region and enables the assessment of clonal restriction of TCR C genes by flow cytometry with 97% sensitivity and 91% specificity.
Assessment of T- cell clonality by flow cytometry is comparable and could replace TCGR molecular study and shows reaching 100% sensitivity and 85% specificity for the diagnosis of LGLL.
Assoc. Prof. Iuri Marinov, CSc.
Head of the Laboratory of Flow Cytometry
Institute of Hematology and Blood Transfusion
European Commission extended deadlines for the implementation of the new IVDR (Regulation No. 2017/746) in order to avoid disruption of the supply of in vitro medical devices.
Accordingly to most recent studies, SCIMP appears to be a key, well defined component in initiation TLR-mediated pro-inflammatory responses in macrophages.
Today we introduce four mouse monoclonal antibody clones, that have been added to our portfolio: Anti-human TROP2 (clone TrMab-6), anti-human TCR gamma/delta (clone 11F2), anti-human CD272 (MIH26), anti-human granzyme A (CB9).