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Recently developed strategy for prevention of cancer relapse due to acquired radioresistance may be based on immunotherapies. One promising approach is based on genetically modified T cells expressing chimeric antigen receptors (CAR).

CD274 (PD-L1) glycoprotein stands at an important immunoregulatory checkpoint.

When performing immunostaining procedures, it is important to know also the backround signal of the immunoglobulin itself, especially when higher antibody concentrations are being used. Hence negative controls represented by conjugates of corresponding antibody isotypes are available.

Obviously, the present pandemic provides a strong impetus to deeper studies on mechanisms of pathologies caused by various respiratory viruses. Better understanding of this area may bring entirely novel approaches to prevention and therapy of diseases caused by such pathogens.

Here we present a short communication of Prof. Vaclav Horejsi, PhD (IMG AS CR) on this Hot Topic.