Recombinant human DR6 (TNFRSF21)/Fc Chimera
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Produced in HEK 293 cells. The extracellular domain of human DR6 (aa 1 - 212) is fused to the Fc portion of human IgG1.
Human DR6 (Death Receptor-6; TNFRSF21) is a type I transmembrane protein containing cytoplasmic death domain, member of the TNF receptor superfamily, expressed in most human tissues.
- Loading control
The recombinant human DR6/Fc chimera can be used as a control for anti-human DR6 antibodies in amounts 15-50 ng.
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
Pan G. et al., Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 1998 431(3):351-6. [Abstract]
For research use only. Not for drug, diagnostic or other use.
Mouse Monoclonal to CD358 / DR6 DR-6-04-EC (IgG1)
Fig. 1. SDS-PAGE
Fig.1. SDS-PAGE Electrophoresis of DR6 / Fc recombinant protein (12% separating gel, 6% stacking gel; reducing conditions).
Lane 1 to 5: DR6 / Fc recombinant protein (2000 ng, 1000 ng, 500 ng, 200 ng, 100 ng per lane). Staining with Coomassie Blue.
Fig. 2. Western Blotting
Fig.2. Western blotting of DR6 / Fc recombinant protein. Reducing conditions.
Lane 1 to 4: immunostaining with rabbit polyclonal antibody specific to DR6 (EC). Detection with Goat anti-rabbit / HRP secondary antibody. Amount of DR6 / Fc recombinant protein loaded on each lane: (1) 150 ng, (2) 75 ng, (3) 30 ng, (4) 15 ng per lane.