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Mouse Monoclonal to CD231

B2D (IgG1)

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Background

CD231 (TALLA-1, T-ALL-asociated antigen 1), also known as tetraspanin 7, is a 150 kDa (under reducing conditions 32-45 kDa) transmembrane glycoprotein of tetraspanin family, expressed in T-type acute lymphoblastic leukemia, neuroblastoma, and neuronal tissue. Mutations of CD231 gene are associated with X-linked mental retardation, Huntington´s chorea, and myotonic dystrophy. CD231 interacts with integrins and may have a role in the control of neurite outgrowth. Antibodies to CD231 are important for detection of T-ALL and are potential targets of its treatment.

Specificity

The mouse monoclonal antibody B2D recognizes CD231 (TALLA-1, tetraspanin 7), a transmembrane glycoprotein expressed in neuronal tissue and T-ALL.

Regulatory Status

Immunogen

Human T-ALL cell line THP-6

Species Reactivity:

  • Human
  • Other not determined

Negative Species:

Applications:

  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry
    Positive control: brain
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Takagi S, Fujikawa K, Imai T, Fukuhara N, Fukudome K, Minegishi M, Tsuchiya S, Konno T, Hinuma Y, Yoshie O: Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily. Int J Cancer. 1995 May 29;61(5):706-15. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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