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Mouse Monoclonal to CD133/1

W6B3C1 (IgG1)

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Background

CD133 (prominin 1) is a 5-transmembrane glycoprotein with extracellular N- and intracellular C-terminus. CD133 function remains to be elucidated, but it can be used as a cancer stem cell marker. Its expression pattern in progenitor cells is similar to CD34, i.e. on hematopoietic stem cells in bone marrow, cord blood, neural stem cells, retinoblastoma, or endothelial precursor cells (not mature endothelial cells). It is being used for identification and isolation of hematopoietic stem cells, including isolation for stem cell transplantation. Expression of CD133 correlates with differentiation of human colon cancer cells.

Specificity

The mouse monoclonal antibody W6B3C1 recognizes a glycosylated epitope 1 on human CD133, a 120 kDa glycoprotein of prominin family, expressed e.g. on progenitor cells. This antibody is important for identification of stem cells and tumor cells.
HLDA VII Workshop

Immunogen

WERI-RB-1 retinoblastoma cell line

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Western Blotting
  • Immunohistochemistry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Liu C, Li Y, Xing Y, Cao B, Yang F, Yang T, Ai Z, Wei Y, Jiang J: The Interaction between Cancer Stem Cell Marker CD133 and Src Protein Promotes Focal Adhesion Kinase (FAK) Phosphorylation and Cell Migration. J Biol Chem. 2016 Jul 22;291(30):15540-50. [Abstract] [Full Text]
  • *Rappa G, Fodstad O, Lorico A: The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells. 2008 Dec;26(12):3008-17. [Abstract] [Full Text]
  • *Hermansen SK, Christensen KG, Jensen SS, Kristensen BW: Inconsistent immunohistochemical expression patterns of four different CD133 antibody clones in glioblastoma. J Histochem Cytochem. 2011 Apr;59(4):391-407. [Abstract] [Full Text]
  • *Feng HL, Liu YQ, Yang LJ, Bian XC, Yang ZL, Gu B, Zhang H, Wang CJ, Su XL, Zhao XM: Expression of CD133 correlates with differentiation of human colon cancer cells. Cancer Biol Ther. 2010 Feb;9(3):216-23. [Abstract]
  • *Dahlrot RH, Hermansen SK, Hansen S, Kristensen BW: What is the clinical value of cancer stem cell markers in gliomas? Int J Clin Exp Pathol. 2013;6(3):334-48. [Abstract] [Full Text]
  • *Brescia P, Ortensi B, Fornasari L, Levi D, Broggi G, Pelicci G: CD133 is essential for glioblastoma stem cell maintenance. Stem Cells. 2013 May;31(5):857-69. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

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