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Mouse Monoclonal to CD39

TU66 (IgG2b)

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  11-184-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
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  1P-184-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
  1P-184-T100 PE 100 tests yes choose region PDF datasheetHTML datasheet buy
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Background

CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), is a cell surface enzyme (with intracellular N- and C-terminus) which hydrolyzes extracellular ATP and ADP to AMP. Inhibition of its enzymatic activity may confer anticancer benefits. The formation of oligomers in the plasma membrane is essential for enzyme activity. It is expressed on Treg cells, and in other cell types, such as mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets. Hydrolysis of ATP and ADP inhibits inflammatory and thrombotic responses. In the nervous system, it regulates purinergic neurotransmission.

Specificity

The mouse monoclonal antibody TU66, also known as T66, recognizes CD39, a 78 kDa cell surface enzyme expressed by regulatory T cells, mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets.
HLDA IV; WS Code A54

Regulatory Status

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Jin Z, Teramoto N, Hayashi K, Liu YX, Jin G, Oka T, Takahashi K, Yoshino T, Akagi T: CD40 ligand stimulation inhibits the proliferation of mantle cell lymphoma lines. Anticancer Res. 2004 Mar-Apr;24(2B):691-7. [Abstract] [Full Text]
  • *Gadeock S, Tran JN, Georgiou JG, Jalilian I, Taylor RM, Wiley JS, Sluyter R: TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes. Biochim Biophys Acta. 2010 Nov;1798(11):2058-66. [Abstract]
  • Coppola A, Coppola L, dalla Mora L, Limongelli FM, Grassia A, Mastrolorenzo L, Gombos G, Lucivero G: Vigorous exercise acutely changes platelet and B-lymphocyte CD39 expression. J Appl Physiol (1985). 2005 Apr;98(4):1414-9. [Abstract] [Full Text]
  • Younas M, Hue S, Lacabaratz C, Guguin A, Wiedemann A, Surenaud M, Beq S, Croughs T, Lelièvre JD, Lvy Y: IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39/ATP axis. J Immunol. 2013 Sep 15;191(6):3161-8. [Abstract] [Full Text]
  • *Wang YM, McRae JL, Robson SC, Cowan PJ, Zhang GY, Hu M, Polhill T, Wang Y, Zheng G, Wang Y, Lee VW, Unwin RJ, Harris DC, Dwyer KM, Alexander SI: Regulatory T cells participate in CD39-mediated protection from renal injury. Eur J Immunol. 2012 Sep;42(9):2441-51. [Abstract]
  • *Nikolova M, Carriere M, Jenabian MA, Limou S, Younas M, Kk A, Hu S, Seddiki N, Hulin A, Delaneau O, Schuitemaker H, Herbeck JT, Mullins JI, Muhtarova M, Bensussan A, Zagury JF, Lelievre JD, Lvy Y: CD39/adenosine pathway is involved in AIDS progression. PLoS Pathog. 2011 Jul;7(7):e1002110. [Abstract] [Full Text]
  • *Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, Hpner S, Centonze D, Bernardi G, Dell'Acqua ML, Rossini PM, Battistini L, Rtzschke O, Falk K: Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood. 2007 Aug 15;110(4):1225-32. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    TU66 purified FC


    Fig. 1. Surface staining of CD39 in human peripheral blood with anti-CD39 (TU66) purified, GAM-APC.

    TU66 PE FC


    Fig. 2. Surface staining of CD39 in human peripheral blood with anti-CD39 (TU66) PE.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIOs term and conditions which are available at www.exbio.cz.
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