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Mouse Monoclonal to CD85g / ILT7

17G10.2 (IgG1)

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Background

CD85g / ILT7 (Immunoglobulin-like transcript 7) is a cell surface protein that is expressed on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response, such as the TLR-induced interferon production. It associates with gamma subunit of the high-affinity IgE receptor to form a receptor complex which transduces the signal through ITAM-associated downstream molecules. Expression of CD85g is downregulated by interleukin 3.

Specificity

The mouse monoclonal antibody 17G10.2 recognizes CD85g / ILT7, a member of leukocyte immunoglobulin-like receptor family expressed on plasmacytoid dendritic cells, but not on myeloid dendritic cells and other peripheral blood leukocytes.

Regulatory Status

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Functional Application
    activation
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Tavano B, Galao RP, Graham DR, Neil SJ, Aquino VN, Fuchs D, Boasso A: Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes. J Immunol. 2013 Mar 15;190(6):2622-30. [Abstract] [Full Text]
  • *Cao W, Rosen DB, Ito T, Bover L, Bao M, Watanabe G, Yao Z, Zhang L, Lanier LL, Liu YJ: Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J Exp Med. 2006 Jun 12;203(6):1399-405. [Abstract] [Full Text]
  • *Tavano B, Boasso A: Effect of immunoglobin-like transcript 7 cross-linking on plasmacytoid dendritic cells differentiation into antigen-presenting cells. PLoS One. 2014 Feb 19;9(2):e89414. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    17G10.2 PE FC


    Fig. 1. Surface staining of CD85g in human peripheral blood with anti-CD85g (17G10.2) PE.


    17G10-2 purified


    Fig. 2. Surface staining of CD85g in human buffy coat cells with anti-CD85g (17G10.2) purified / GAM-APC.

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