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Rat Monoclonal to CD267 / TACI

1A1 (IgG2a)

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CD267 / TACI (Transmembrane Activator Calcium modulator and cyclophilin ligand Interactor), a TNFR superfamily transmembrane protein, is expressed on B cells (predominantly on CD27+ memory cells), multiple myeloma cells and B cell chronic lymphocytic leukemia (B-CLL). Its triggering leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. It plays a crucial role in humoral immunity. Mutations in CD267 are associated with common variable immunodeficiency and IgA deficiency.


The rat monoclonal antibody 1A1 recognizes CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells.
HLDA 8 Workshop

Regulatory Status


CD267-transfected RBL cells

Species Reactivity:

  • Human

Negative Species:


  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Koarada S, Tada Y, Suematsu R, Soejima S, Inoue H, Ohta A, Nagasawa K: Phenotyping of P105-negative B cell subsets in patients with systemic lupus erythematosus. Clin Dev Immunol. 2012;2012:198206. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    1A1 purified

    Fig. 1. Surface staining of human peripheral blood with anti-human CD267 (1A1) purified, DAR-APC.

    1A1 PE

    Fig. 2. Surface staining of human peripheral blood with anti-human CD267 (1A1) PE.

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