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Rat Monoclonal to CD267 / TACI

1A1 (IgG2a)

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Background

CD267 / TACI (Transmembrane Activator Calcium modulator and cyclophilin ligand Interactor), a TNFR superfamily transmembrane protein, is expressed on B cells (predominantly on CD27+ memory cells), multiple myeloma cells and B cell chronic lymphocytic leukemia (B-CLL). Its triggering leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. It plays a crucial role in humoral immunity. Mutations in CD267 are associated with common variable immunodeficiency and IgA deficiency.

Specificity

The rat monoclonal antibody 1A1 recognizes CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells.
HLDA 8 Workshop

Regulatory Status

Immunogen

CD267-transfected RBL cells

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Koarada S, Tada Y, Suematsu R, Soejima S, Inoue H, Ohta A, Nagasawa K: Phenotyping of P105-negative B cell subsets in patients with systemic lupus erythematosus. Clin Dev Immunol. 2012;2012:198206. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    1A1 purified


    Fig. 1. Surface staining of human peripheral blood with anti-human CD267 (1A1) purified, DAR-APC.


    1A1 PE


    Fig. 2. Surface staining of human peripheral blood with anti-human CD267 (1A1) PE.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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