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Mouse Monoclonal to CD1a

SK9 (IgG2b)

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Product No. Form Quantity Stock Price Datasheet Shop
  11-174-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-174-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1F-174-T025 FITC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1F-174-T100 FITC 100 tests yes choose region PDF datasheetHTML datasheet buy
  1P-174-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
  1P-174-T100 PE 100 tests yes choose region PDF datasheetHTML datasheet buy
  1A-174-T025 APC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1A-174-T100 APC 100 tests yes choose region PDF datasheetHTML datasheet buy
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Background

CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.

Specificity

The mouse monoclonal antibody SK9 recognizes CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas.

Regulatory Status

Immunogen

Human thymocytes

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Immunoprecipitation
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Zimmer MI, Larregina AT, Castillo CM, Capuano S 3rd, Falo LD Jr, Murphey-Corb M, Reinhart TA, Barratt-Boyes SM: Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS. Blood. 2002 Apr 15;99(8):2859-68. [Abstract] [Full Text]
  • *Brown KN, Trichel A, Barratt-Boyes SM: Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS. J Immunol. 2007 Jun 1;178(11):6958-67. [Abstract] [Full Text]
  • *Tenca C, Merlo A, Zarcone D, Saverino D, Bruno S, De Santanna A, Ramarli D, Fabbi M, Pesce C, Deaglio S, Ciccone E, Malavasi F, Grossi CE: Death of T cell precursors in the human thymus: a role for CD38. Int Immunol. 2003 Sep;15(9):1105-16. [Abstract] [Full Text]
  • *Awasthi S, Wolf R, White G: Ontogeny and phagocytic function of baboon lung dendritic cells. Immunol Cell Biol. 2009 Jul;87(5):419-27. [Abstract] [Full Text]
  • *Kader M, Smith AP, Guiducci C, Wonderlich ER, Normolle D, Watkins SC, Barrat FJ, Barratt-Boyes SM: Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS Pathog. 2013;9(7):e1003530. [Abstract] [Full Text]
  • *Wood GS, Burns BF, Dorfman RF, Warnke RA: The immunohistology of non-T cells in the acquired immunodeficiency syndrome. Am J Pathol. 1985 Sep;120(3):371-9. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    1A-174

    Fig. 1. Surface staining of MOLT-4 cells with anti-CD1a (SK9) APC.


    1p-174

    Fig. 2. Surface staining of MOLT-4 cells with anti-CD1a (SK9) PE.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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