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Rabbit Polyclonal to Mycobacterium tuberculosis antigen GlcB

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Background

The Mycobacterium tuberculosis antigen GlcB (malate synthase) catalyzes synthesis of malate from glyoxylate and acetyl-CoA. This reaction is part of the glyoxylate cycle, which allows the bacterium to derive its carbon requirements from two-carbon compounds by bypassing the two carbocylation steps of the cytric acid cycle. This enzyme is up-regulated in response to phagocytosis and it is a virulence or persistence factor.

Specificity

The rabbit polyclonal antibody to GlcB reacts with Mycobacterium tuberculosis protein GlcB (malate synthase, Rv1837c).

Regulatory Status

Immunogen

Recombinant Mycobacterium tuberculosis GlcB produced in E. coli

Species Reactivity:

  • Mycobacterium tuberculosis

Negative Species:

Applications:

  • Western Blotting
  • ELISA
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Anstrom DM, Remington SJ: The product complex of M. tuberculosis malate synthase revisited. Protein Sci. 2006 Aug;15(8):2002-7. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    anti-GlcB
    Fig. 1


    Fig. 1. Western blotting analysis of polyclonal anti-Mycobacterium tuberculosis antigen GlcB.
    A) cell lysate of non-transfected E. coli
    B) cell lysate of GlcB-transfected E. coli

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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