Rabbit Polyclonal to Mycobacterium tuberculosis antigen GlcB
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The Mycobacterium tuberculosis antigen GlcB (malate synthase) catalyzes synthesis of malate from glyoxylate and acetyl-CoA. This reaction is part of the glyoxylate cycle, which allows the bacterium to derive its carbon requirements from two-carbon compounds by bypassing the two carbocylation steps of the cytric acid cycle. This enzyme is up-regulated in response to phagocytosis and it is a virulence or persistence factor.
The rabbit polyclonal antibody to GlcB reacts with Mycobacterium tuberculosis protein GlcB (malate synthase, Rv1837c).
Recombinant Mycobacterium tuberculosis GlcB produced in E. coli
- Mycobacterium tuberculosis
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
*Anstrom DM, Remington SJ: The product complex of M. tuberculosis malate synthase revisited. Protein Sci. 2006 Aug;15(8):2002-7. [Abstract] [Full Text]
For research use only. Not for drug, diagnostic or other use.
Western blotting analysis of polyclonal anti-Mycobacterium tuberculosis antigen GlcB
A) cell lysate of non-transfected E. coli
B) cell lysate of GlcB-transfected E. coli