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Rabbit Polyclonal to Mycobacterium tuberculosis antigen Acr2

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Background

The Mycobacterium tuberculosis antigen Acr2 (alpha-crystallin-related protein 2), also known as HrpA or Hsp20, is a small heat shock protein, which forms oligomeric assemblies. Expression of Acr2 is induced by heat shock, oxidative stress, and uptake by macrophages. It evokes a vigorous early immune response.

Specificity

The rabbit polyclonal antibody to Acr2 reacts with Mycobacterium tuberculosis protein Acr2 (Rv0251c, Hsp20).

Regulatory Status

Immunogen

Recombinant Mycobacterium tuberculosis Acr2 produced in E. coli

Species Reactivity:

  • Mycobacterium tuberculosis

Negative Species:

Applications:

  • Western Blotting
  • ELISA
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Kennaway CK, Benesch JL, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR, Keep NH: Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem. 2005 Sep 30;280(39):33419-25. [Abstract] [Full Text]
  • *Wilkinson KA, Stewart GR, Newton SM, Vordermeier HM, Wain JR, Murphy HN, Horner K, Young DB, Wilkinson RJ: Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2. J Immunol. 2005 Apr 1;174(7):4237-43. [Abstract] [Full Text]
  • *Stewart GR, Newton SM, Wilkinson KA, Humphreys IR, Murphy HN, Robertson BD, Wilkinson RJ, Young DB: The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Mol Microbiol. 2005 Feb;55(4):1127-37. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    anti-Acr2
    Fig. 1


    Fig. 1. Western blotting analysis of polyclonal anti-Mycobacterium tuberculosis antigen Acr2.
    A) cell lysate of non-transfected E. coli
    B) cell lysate of Acr2-transfected E. coli

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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