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Rabbit Polyclonal to Mycobacterium tuberculosis antigen Acr2

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The Mycobacterium tuberculosis antigen Acr2 (alpha-crystallin-related protein 2), also known as HrpA or Hsp20, is a small heat shock protein, which forms oligomeric assemblies. Expression of Acr2 is induced by heat shock, oxidative stress, and uptake by macrophages. It evokes a vigorous early immune response.


The rabbit polyclonal antibody to Acr2 reacts with Mycobacterium tuberculosis protein Acr2 (Rv0251c, Hsp20).

Regulatory Status


Recombinant Mycobacterium tuberculosis Acr2 produced in E. coli

Species Reactivity:

  • Mycobacterium tuberculosis

Negative Species:


  • Western Blotting
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Kennaway CK, Benesch JL, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR, Keep NH: Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem. 2005 Sep 30;280(39):33419-25. [Abstract] [Full Text]
  • *Wilkinson KA, Stewart GR, Newton SM, Vordermeier HM, Wain JR, Murphy HN, Horner K, Young DB, Wilkinson RJ: Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2. J Immunol. 2005 Apr 1;174(7):4237-43. [Abstract] [Full Text]
  • *Stewart GR, Newton SM, Wilkinson KA, Humphreys IR, Murphy HN, Robertson BD, Wilkinson RJ, Young DB: The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Mol Microbiol. 2005 Feb;55(4):1127-37. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    Fig. 1

    Fig. 1. Western blotting analysis of polyclonal anti-Mycobacterium tuberculosis antigen Acr2.
    A) cell lysate of non-transfected E. coli
    B) cell lysate of Acr2-transfected E. coli

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