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Rabbit Polyclonal to Mycobacterium tuberculosis antigen Acr1

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Background

The Mycobacterium tuberculosis antigen Acr1 (alpha-crystallin-related protein 1), also known as Hsp16.3, is a small heat shock protein (16 kDa), which forms oligomeric assemblies. Expression of Acr1 is induced by exposure to hypoxia or nitric oxide and is associated with bacterial persistence in a non-replicating state.

Specificity

The rabbit polyclonal antibody to Acr1 reacts with Mycobacterium tuberculosis protein Acr1 (Rv2031c, Hsp16.3).

Regulatory Status

Immunogen

Recombinant Mycobacterium tuberculosis Acr1 produced in E. coli

Species Reactivity:

  • Mycobacterium tuberculosis

Negative Species:

Applications:

  • Western Blotting
  • ELISA
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • Shi C, Zhang H, Zhang T, Wang X, Bai B, Zhao Y, Zhang C, Xu Z: New alternative vaccine component against mycobacterium tuberculosis--heat shock protein 16.3 or its T-cell epitope. Scand J Immunol. 2009 Nov;70(5):465-74. [Abstract]
  • *Kennaway CK, Benesch JL, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR, Keep NH: Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem. 2005 Sep 30;280(39):33419-25. [Abstract] [Full Text]
  • *Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Tadokera R, Conesa-Botella A, Seldon R, Rangaka MX, Rebe K, Pepper DJ, Morroni C, Colebunders R, Maartens G, Wilkinson RJ: Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome. Am J Respir Crit Care Med. 2012 Aug 15;186(4):369-77 [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    anti-Acr1
    Fig. 1


    Fig. 1. Western blotting analysis of polyclonal anti-Mycobacterium tuberculosis antigen Acr1.
    A) cell lysate of non-transfected E. coli
    B) cell lysate of Acr1-transfected E. coli

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