System Certification ISO 9001:2000
Exbio Antibodies CZ / SK eShop
by categories | a-z list | Application type: Flow Cytometry | Immunohistochemistry | Functional Studies

Mouse Monoclonal to CD193 / CCR3

5E8 (IgG2b)

Technical Information Request    Inquiry for Bulk Prices

Product No. Form Quantity Stock Price Datasheet Shop
  11-161-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-161-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
New PB-161-T100 Pacific Blue™ 100 tests yes choose region PDF datasheetHTML datasheet buy
New 1F-161-T100 FITC 100 tests yes choose region PDF datasheetHTML datasheet buy
New A4-161-T100 Alexa Fluor® 488 100 tests yes choose region PDF datasheetHTML datasheet buy
  1P-161-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
  1P-161-T100 PE 100 tests yes choose region PDF datasheetHTML datasheet buy
  1A-161-T025 APC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1A-161-T100 APC 100 tests yes choose region PDF datasheetHTML datasheet buy
New A6-161-T100 Alexa Fluor® 647 100 tests yes choose region PDF datasheetHTML datasheet buy
- In stock! Ready for immediate despatch - Manufacture on order

Background

CD193 / CCR3 is a G-protein coupled receptor for several chemokines, namely CCL11 (eotaxin), CCL26 (eotaxin-3), CCL7 (MCP-4), or CCL5 (RANTES). It is highly expressed on eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. CD193 is the key eosinophil chemokine receptor responsible for regulation of eosinophil migration and function. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.

Specificity

The mouse monoclonal antibody 5E8 recognizes CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.

Regulatory Status

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Morshed M, Hlushchuk R, Simon D, Walls AF, Obata-Ninomiya K, Karasuyama H, Djonov V, Eggel A, Kaufmann T, Simon HU, Yousefi S: NADPH oxidase-independent formation of extracellular DNA traps by basophils. J Immunol. 2014 Jun 1;192(11):5314-23. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    5E8 purified FC


    Fig. 1. Surface staining of CD193 in human peripheral blood with anti-human CD193 (5E8) purified, GAM-APC.

    5E8 PE


    Fig. 2. Surface staining of CD193 in human peripheral blood with anti-human CD193 (5E8) PE.

    5E8 APC FC

    Fig. 3. Surface staining of CD193 in human peripheral blood with anti-human CD193 (5E8) APC.






    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
    Alexa Fluor®, Pacific Blue™ and Pacific Orange™ are registred trademarks of Molecular Probes Inc., Eugene, OR, USA. (licence label)
    DyLight® is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
    Cy™ and CyDye™ are registered trademarks of GE Healthcare.
    © 2003 EXBIO. All rights reserved.
    terms and conditions | privacy policy