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Mouse Monoclonal to CD184 / CXCR4

12G5 (IgG2a)

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CD184, also known as CXCR4 or fusin, is a receptor for the C-X-C chemokine SDF-1. It is expressed mainly in hematopoietic cells, vascular endothelium, and neural tissue. CD184 is a G-protein coupled receptor containing extracellular N-terminal, seven transmembrane domains and intracellular C-terminal domain. It transduces signal by increasing the intracellular calcium level. CD184 plays an essential role in vascularization of the gastrointestinal tract, and is involved in cerebellar development and in hematopoiesis. It is also a coreceptor (with CD4) for HIV-1 X4 virus and a primary receptor for some HIV-2 isolates.


The mouse monoclonal antibody 12G5 recognizes CD184, a 45 kDa G-protein-linked CXC chemokine receptor widely expressed on blood and tissue cells.
HLDA 7; WS Code 70204

Regulatory Status


CP-MAC-infected Sup-T1 cells

Species Reactivity:

  • Human
  • Non-Human Primates

Negative Species:


  • Flow Cytometry
  • Immunohistochemistry (paraffin sections)
  • Immunocytochemistry
  • Functional Application
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Grundler R, Brault L, Gasser C, Bullock AN, Dechow T, Woetzel S, Pogacic V, Villa A, Ehret S, Berridge G, Spoo A, Dierks C, Biondi A, Knapp S, Duyster J, Schwaller J: Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J Exp Med. 2009 Aug 31;206(9):1957-70. [Abstract] [Full Text]
  • *Uy GL, Rettig MP, Motabi IH, McFarland K, Trinkaus KM, Hladnik LM, Kulkarni S, Abboud CN, Cashen AF, Stockerl-Goldstein KE, Vij R, Westervelt P, DiPersio JF: A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood. 2012 Apr 26;119(17):3917-24. [Abstract] [Full Text]
  • *Campioni D, Zauli G, Gambetti S, Campo G, Cuneo A, Ferrari R, Secchiero P: In vitro characterization of circulating endothelial progenitor cells isolated from patients with acute coronary syndrome. PLoS One. 2013;8(2):e56377. [Abstract] [Full Text]
  • *Koopman G, Mortier D, Hofman S, Koutsoukos M, Bogers WM, Wahren B, Voss G, Heeney JL: Acute-phase CD4+ T-cell proliferation and CD152 upregulation predict set-point virus replication in vaccinated simian-human immunodeficiency virus strain 89.6p-infected macaques. J Gen Virol. 2009 Apr;90(Pt 4):915-26. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    12G5 PE
    Fig. 1

    Fig. 1. Surface staining of human peripheral blood leukocytes with anti-human CD184 (12G5) PE.

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