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Mouse Monoclonal to CD49c / Integrin alpha 3

ASC-1 (IgG1)

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Background

CD49c / Integrin alpha 3 is a type I transmembrane glycoprotein proteolytically cleaved into two disulfide linked chains. It noncovalently associates with CD29 (integrin beta 1) to form the VLA-3 complex, an adhesion receptor for extracellular matrix components (fibronectin, laminin 1, laminin 5, entactin, and collagen). It is expressed on adherent cells, mainly on fibroblasts, epithelial cells and endothelial cells.

Specificity

The mouse monoclonal antibody ASC-1 recognizes CD49c (integrin alpha 3), a transmembrane glycoprotein composed of disulfide linked 125 kDa and 30 kDa chains, and expressed on adherent cell lines and to a lesser extent on T and B cells and monocytes.
HLDA VI; WS Code A002

Regulatory Status

Immunogen

Human SSC-9 cell line (squamous cell carcinoma)

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry (frozen sections)
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Pattaramalai S, Skubitz KM, Skubitz AP: A novel recognition site on laminin for the alpha 3 beta 1 integrin. Exp Cell Res. 1996 Feb 1;222(2):281-90. [Abstract]
  • *Skubitz AP, Bast RC, Wayner EA, Letourneau PC, Wilke MS: Expression of alpha 6 and beta 4 integrins in serous ovarian carcinoma correlates with expression of the basement membrane protein laminin. Am J Pathol. 1996 May;148(5):1445-61. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    ASC-1 purified


    Fig. 1. Surface staining of HeLa cells with anti-CD49c (ASC-1) purified, GAM-APC.


    ASC-1 PE


    Fig. 2. Surface staining of HeLa cells with anti-CD49c (ASC-1) PE.

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