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Mouse Monoclonal to TCR gamma/delta

B1 (IgG1)

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  11-147-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
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Background

The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.

Specificity

The mouse monoclonal antibody B1 (also known as B1.1) recognizes TCR gamma/delta, the subtype of T cell receptor expressed mainly in epithelial tissues and at the sites of infection.

Regulatory Status

Species Reactivity:

  • Human
  • Non-Human Primates

Negative Species:

Applications:

  • Flow Cytometry
  • Immunohistochemistry (paraffin sections)
  • Immunohistochemistry (frozen sections)
  • Functional Application
    blocking
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Rodríguez-Gago M, de Heredia A, Ramírez P, Parrilla P, Aparicio P, Yélamos J: Human anti-porcine gammadelta T-cell xenoreactivity is inhibited by human FasL expression on porcine endothelial cells. Transplantation. 2001 Aug 15;72(3):503-9. [Abstract]
  • *Lehmann FS, Terracciano L, Carena I, Baeriswyl C, Drewe J, Tornillo L, De Libero G, Beglinger C: In situ correlation of cytokine secretion and apoptosis in Helicobacter pylori-associated gastritis. Am J Physiol Gastrointest Liver Physiol. 2002 Aug;283(2):G481-8. [Abstract] [Full Text]
  • *Correia DV, Fogli M, Hudspeth K, da Silva MG, Mavilio D, Silva-Santos B: Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells. Blood. 2011 Jul 28;118(4):992-1001. [Abstract] [Full Text]
  • *Bordignon M, Belloni Fortina A, Pigozzi B, Alaibac M: γδ T cells as potential contributors to the progression of parapsoriasis to mycosis fungoides. Mol Med Rep. 2008 Jul-Aug;1(4):485-8. [Abstract]
  • *Pöllinger B, Junt T, Metzler B, Walker UA, Tyndall A, Allard C, Bay S, Keller R, Raulf F, Di Padova F, O'Reilly T, Horwood NJ, Patel DD, Littlewood-Evans A: Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    B1 FITC
    Fig. 1


    Fig. 1. Surface staining of human peripheral blood lymphocytes with anti-human TCR gamma/delta (B1) FITC.



    B1 PE
    Fig. 2


    Fig. 2. Surface staining of human peripheral blood lymphocytes with anti-human TCR gamma/delta (B1) PE.


    B1 purified


    Fig. 3. Surface staining of human peripheral blood lymphocytes with anti-human TCR gamma/delta (B1) purified, GAM-APC.


    B1 PE-Cy7


    Fig. 4. Surface staining of human peripheral blood lymphocytes with anti-human TCR gamma/delta (B1) PE-CyTM7.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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