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Mouse Monoclonal to CD89

A59 (IgG1)

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  11-139-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
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  1F-139-T025 FITC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1F-139-T100 FITC 100 tests yes choose region PDF datasheetHTML datasheet buy
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CD89 (Fc-alpha-R) is a type I transmembrane glycoprotein serving as a receptor for IgA. Soluble CD89 is detectable in serum and retains its IgA binding capacity. For signal transduction the association with FcR gamma chain homodimers is needed. CD89 is expressed on granulocytes, monocytes, macrophages, dendritic cells and myeloid cell lines. Its expression is upregulated in presence of IgA immune complexes, stimulators (such as LPS, PMA), TNF alpha, IL1 beta or GM-CSF, and it is downregulated in presence of TGF beta and suramin. Binding of IgA-opsonized targets to CD89 leads to phagocytic and cytotoxic processes of the immunologic defense.


The mouse monoclonal antibody A59 recognizes CD89, a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes, monocytes and macrophages.

Regulatory Status


Ag8.653 myeloma cells

Species Reactivity:

  • Human
  • Non-Human Primates

Negative Species:


  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Schenk M, Bouchon A, Seibold F, Mueller C: TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest. 2007 Oct;117(10):3097-106. [Abstract] [Full Text]
  • *Barratt J, Greer MR, Pawluczyk IZ, Allen AC, Bailey EM, Buck KS, Feehally J: Identification of a novel Fcalpha receptor expressed by human mesangial cells. Kidney Int. 2000 May;57(5):1936-48. [Abstract] [Full Text]
  • *van Egmond M, van Spriel AB, Vermeulen H, Huls G, van Garderen E, van de Winkel JG: Enhancement of polymorphonuclear cell-mediated tumor cell killing on simultaneous engagement of fcgammaRI (CD64) and fcalphaRI (CD89). Cancer Res. 2001 May 15;61(10):4055-60. [Abstract] [Full Text]
  • *Honorio-Franša AC, Launay P, Carneiro-Sampaio MM, Monteiro RC: Colostral neutrophils express Fc alpha receptors (CD89) lacking gamma chain association and mediate noninflammatory properties of secretory IgA. J Leukoc Biol. 2001 Feb;69(2):289-96. [Abstract] [Full Text]
  • *Wu J, Ji C, Xie F, Langefeld CD, Qian K, Gibson AW, Edberg JC, Kimberly RP: FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA. J Immunol. 2007 Mar 15;178(6):3973-82. [Abstract] [Full Text]
  • *Rogers KA, Scinicariello F, Attanasio R: Identification and characterization of macaque CD89 (immunoglobulin A Fc receptor). Immunology. 2004 Oct;113(2):178-86. [Abstract]
  • *van Dijk TB, Bracke M, Caldenhoven E, Raaijmakers JA, Lammers JW, Koenderman L, de Groot RP: Cloning and characterization of Fc alpha Rb, a novel Fc alpha receptor (CD89) isoform expressed in eosinophils and neutrophils. Blood. 1996 Dec 1;88(11):4229-38. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    A59 PE FC

    Fig. 1. Surface staining of CD89 in human peripheral blood with anti-CD89 (A59) PE.

    A59 FITC

    Fig. 2. Surface staining of CD89 in human peripheral blood with anti-CD89 (A59) FITC.

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