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Mouse Monoclonal to CD172b / SIRP beta

B4B6 (IgG1)

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CD172b, the signal-regulatory protein beta (SIRP beta) is a disulfide-linked homodimer expressed on myeloid cells including monocytes and dendritic cells. Similarly to CD172a, it serves as a negative regulator of tyrosine kinase-coupled signaling processes. Unlike CD172a, the CD172b protein does not possess the cytoplasmic domain, but instead its transmembrane domain can interact with another transmembrane protein DAP-12, which contains ITAM sequences in its intracellular domain and links CD172b to the downstream signaling molecules. The result is e.g. regulation of neutrophil transepithelial migration.


The mouse monoclonal antibody B4B6 recognizes CD172b, an approximately 50 kDa transmembrane glycoprotein expressed on myeloid cells.

Regulatory Status


NIH-3T3 cells transfected with human CD172b

Species Reactivity:

  • Human

Negative Species:


  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Schäkel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M: CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF. J Exp Med. 2013 Jun 3;210(6):1251-63. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    B4B6 pur

    Fig. 1. Surface staining of human peripheral blood cells with anti-human CD172b (B4B6) purified, GAM-APC.

    B4B5 PE

    Fig. 2. Surface staining of human peripheral blood cells with anti-human CD172b (B4B6) PE.

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