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Mouse Monoclonal to CD172b / SIRP beta

B4B6 (IgG1)

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Background

CD172b, the signal-regulatory protein beta (SIRP beta) is a disulfide-linked homodimer expressed on myeloid cells including monocytes and dendritic cells. Similarly to CD172a, it serves as a negative regulator of tyrosine kinase-coupled signaling processes. Unlike CD172a, the CD172b protein does not possess the cytoplasmic domain, but instead its transmembrane domain can interact with another transmembrane protein DAP-12, which contains ITAM sequences in its intracellular domain and links CD172b to the downstream signaling molecules. The result is e.g. regulation of neutrophil transepithelial migration.

Specificity

The mouse monoclonal antibody B4B6 recognizes CD172b, an approximately 50 kDa transmembrane glycoprotein expressed on myeloid cells.
HLDA 8

Regulatory Status

Immunogen

NIH-3T3 cells transfected with human CD172b

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Schäkel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M: CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF. J Exp Med. 2013 Jun 3;210(6):1251-63. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    B4B6 pur


    Fig. 1. Surface staining of human peripheral blood cells with anti-human CD172b (B4B6) purified, GAM-APC.


    B4B5 PE


    Fig. 2. Surface staining of human peripheral blood cells with anti-human CD172b (B4B6) PE.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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