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Mouse Monoclonal to CD167a

51D6 (IgG3)

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Background

CD167a, also known as e.g. discoidin domain receptor tyrosine kinase 1 (DDR1), tyrosine kinase receptor E (TRKE), cell adhesion kinase (CAK), or neuroepithelial tyrosine kinase 4 (NEP, NTRK4), is a transmembrane receptor tyrosine kinase expressed predominantly in epithelial cells. It has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. After binding to fibrilar collagens I, II, III, V, or basement membrane collagens IV and VIII, CD167a becomes activated and autophosphorylated and transduces collagen-induced signaling.

Specificity

The mouse monoclonal antibody 51D6 recognizes CD167a, an approximately 97-101 kDa receptor tyrosine kinase expressed mainly on epithelial cells, but also on B cells and dendritic cells.

Regulatory Status

Immunogen

CD167a-transfected NIH-3T3 cells

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Immunoprecipitation
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

References

  • Unpublished.
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    51D6 pur


    Fig. 1. Surface staining of MCF-7 cell line with anti-human CD167a (51D6) purified, GAM-APC.


    51D6 PE


    Fig. 2. Surface staining of MCF-7 cell line with anti-human CD167a (51D6) PE.

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