Mouse Monoclonal to CD328 / Siglec-7
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, also known as Siglec-7 or p75/AIRM1, is a 75 kDa type I transmembrane glycoprotein of sialic acid-binding immunoglobulin-like lectin (Siglec) family. CD328 binds to sialylated glycans with alpha2,6 sialyl and alpha2,8 disyalyl residues and mediates sialic acid-dependent cell-cell binding. As it contains in its intracellular part the immunoreceptor tyrosine-based inhibitory motif (ITIM), it serves as an inhibitory receptor, e.g. of NK cells.
The mouse monoclonal antibody 6-434 recognizes CD328 (Siglec-7), a 75 kDa transmembrane glycoprotein expressed mainly on NK cells, dendritic cells and monocytes.
HLDA 8; WS Code ARN-80652
human dendritic cells
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
For research use only. Not for drug, diagnostic or other use.
Surface staining of CD328 in human peripheral blood with anti-CD328 (6-434