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Mouse Monoclonal to CD328 / Siglec-7

6-434 (IgG1)

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CD328, also known as Siglec-7 or p75/AIRM1, is a 75 kDa type I transmembrane glycoprotein of sialic acid-binding immunoglobulin-like lectin (Siglec) family. CD328 binds to sialylated glycans with alpha2,6 sialyl and alpha2,8 disyalyl residues and mediates sialic acid-dependent cell-cell binding. As it contains in its intracellular part the immunoreceptor tyrosine-based inhibitory motif (ITIM), it serves as an inhibitory receptor, e.g. of NK cells.


The mouse monoclonal antibody 6-434 recognizes CD328 (Siglec-7), a 75 kDa transmembrane glycoprotein expressed mainly on NK cells, dendritic cells and monocytes.
HLDA 8; WS Code ARN-80652

Regulatory Status


human dendritic cells

Species Reactivity:

  • Human

Negative Species:


  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.


  • Unpublished.
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    6-434 PE FC

    Fig. 1. Surface staining of CD328 in human peripheral blood with anti-CD328 (6-434) PE.

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