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Mouse Monoclonal to Lysozyme

LZ598-10G9 (IgG1)

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Background

Lysozyme is anti-bacterial enzyme found mainly in milk, saliva, tears, plasma, spleen, mucus, and leukocytes (e.g. in cytoplasmic granules of neutrophils). It damages bacterial cell walls by hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Lysozyme is part of the innate immune system. It protects wet body surfaces, such as conjunctiva. Reduced lysozyme levels have been associated with bronchopulmonary dysplasia in newborns. On the other hand high lysozyme blood levels produced for example by myelomonocytic leukemia cells can lead to kidney failure and low blood potassium.

Specificity

The mouse monoclonal antibody LZ598-10G9 recognizes lysozyme, an approximately 17 kDa antibacterial enzyme, which is being used as a marker for the lineage diagnosis of acute leukemias.

Regulatory Status

Immunogen

human lysozyme

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
    Application note: intracellular staining
  • Immunocytochemistry
  • Mass Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Strobl H, Knapp W: Myeloid cell-associated lysosomal proteins as flow cytometry markers for leukocyte lineage classification. J Biol Regul Homeost Agents. 2004 Jul-Dec;18(3-4):335-9. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    LZ598-10G9 MC

    Fig. 1. Intracellular staining (mass cytometry) of PBMC after Ficoll-Paque separation with anti-human lysozyme (LZ598-10G9) Gd155. Gated on native.


    LZ598-10G9 pur


    Fig. 2. Intracellular staining of lysozyme in human peripheral blood with anti-lysozyme (LZ598-10G9) purified, GAM-FITC.



    LZ598-10G9 PE


    Fig. 3. Intracellular staining of lysozyme in human peripheral blood with anti-lysozyme (LZ598-10G9) PE.


    L243 FITC


    Fig. 4. Intracellular staining of lysozyme in human peripheral blood with anti-lysozyme (LZ598-10G9) FITC.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
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