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Mouse Monoclonal to Lactoferrin

LF5-1D2 (IgG1)

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Background

Lactoferrin is an iron-binding glycoprotein of the transferrin family, which is released to most biological fluids, with particularly high levels in milk. It has anti-inflammatory (e.g. sequestering of lipopolysaccharides), anti-microbial (e.g. blocking of viral attachment to the target cell), and immunomodulatory properties and can prevent infections in young children. Lactoferrin is considered to bridge the innate and adaptive immune responses. It also participates in iron homeostasis, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Besides biological fluids it is also found in the secondary granules of neutrophils.

Specificity

The mouse monoclonal antibody LF5-1D2 recognizes lactoferrin, an iron-binding glycoprotein of about 90 kDa, which has anti-inflammatory, immunomodulatory and anti-microbial properties.

Regulatory Status

Immunogen

human lactoferrin

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
    intracellular
  • ELISA
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • Wakabayashi H, Oda H, Yamauchi K, Abe F: Lactoferrin for prevention of common viral infections. J Infect Chemother. 2014 Aug 30. pii: S1341-321X(14)00286-4. [Abstract]
  • *Turin CG, Zea-Vera A, Pezo A, Cruz K, Zegarra J, Bellomo S, Cam L, Llanos R, Castañeda A, Tucto L, Ochoa TJ; NEOLACTO Research Group: Lactoferrin for prevention of neonatal sepsis. Biometals. 2014 Oct;27(5):1007-16. doi: 10.1007/s10534-014-9754-3. [Abstract]
  • *Siqueiros-Cendón T, Arévalo-Gallegos S, Iglesias-Figueroa BF, García-Montoya IA, Salazar-Martínez J, Rascón-Cruz Q: Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. 2014 May;35(5):557-66. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    LF5-1D2 pur


    Fig. 1. Intracellular staining of human peripheral blood cells using anti-lactoferrin (LF5-1D2) purified, GAM-APC.

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