Mouse Monoclonal to Basic Cytokeratins
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are a subfamily of intermediate filaments and are characterized by remarkable biochemical diversity. Cytokeratins are represented in epithelial tissues by at least 20 different polypeptides, molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20 and divided into the type I (acidic cytokeratins 9-20) and type II (basic to neutral cytokeratins 1-8) families.
Mouse monoclonal antibody AE3 recognizes all basic type cytokeratins, namely K1-K8 (58-67 kDa). This antibody reacts with all layers of epidermis (basal layer and above) and is an excellent marker for distinguishing carcinomas from non-epithelial tumours.
Human epidermal keratins
- Non-Human Primates
- Western Blotting
- Immunohistochemistry (paraffin sections)
- Immunohistochemistry (frozen sections)
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
Product Specific References
*Yeh IT, Miller AR: Staining of sentinel node reticulum cells with cytokeratin antibody AE3. Arch Pathol Lab Med. 2002 Mar;126(3):248-9. [Abstract]
*Zhang B, Chen Y, Han Z, Ris H, Zhai Z: The role of keratin filaments during nuclear envelope reassembly in Xenopus egg extracts. FEBS Lett. 1998 May 22;428(1-2):52-6. [Abstract]
*Listrom MB, Dalton LW: Comparison of keratin monoclonal antibodies MAK-6, AE1:AE3, and CAM-5.2. Am J Clin Pathol. 1987 Sep;88(3):297-301. [Abstract]
*Woodcock-Mitchell J, Eichner R, Nelson WG, Sun TT: Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol. 1982 Nov;95(2 Pt 1):580-8. [Abstract] [Full Text]
*Hunt RC, Davis AA: Altered expression of keratin and vimentin in human retinal pigment epithelial cells in vivo and in vitro. J Cell Physiol. 1990 Nov;145(2):187-99. [Abstract]
For research use only. Not for drug, diagnostic or other use.