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Mouse Monoclonal to CD157

SY11B5 (IgG1)

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Background

CD157 (cADPr hydrolase 2) is a GPI-anchored ectoenzyme possessing ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activity. It uses NAD and cADP-ribose as substrates. CD157 is expressed on granulocytes, monocytes, macrophages, follicular dendritic cells, bone marrow stromal cells and human umbilical cord vein endothelial cells. In case of rheumatoid arthritis is expression is often higher and it is also differentially expressed in the myeloid leukemias. It may also have a signaling role.

Specificity

The mouse monoclonal antibody SY11B5 recognizes CD157, an approximately 45 kDa GPI-anchored protein expressed mainly on monocytes, macrophages, granulocytes and bone marrow stromal cells.

Regulatory Status

Immunogen

Human CD157

Species Reactivity:

  • Human
  • Non-Human Primates

Negative Species:

Applications:

  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
    Application note:non-reducing conditions
  • Immunohistochemistry (frozen sections)
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

References

  • Unpublished.
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    SY11B5 APC


    Fig. 1. Surface staining of human peripheral blood leukocytes with anti-human CD157 (SY11B5) APC.


    SY11B5 purified


    Fig. 2. Surface staining of human peripheral blood leukocytes with anti-human CD157 (SY11B5) purified / GAM-APC.


    SY11B5 PE


    Fig. 3. Surface staining of human peripheral blood leukocytes with anti-human CD157 (SY11B5) PE.


    SY11B1 FITC


    Fig. 4. Surface staining of human peripheral blood leukocytes with anti-human CD157 (SY11B5) FITC.

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