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Mouse Monoclonal to CD101

BB27 (IgG1)

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CD101 is a type I transmembrane glycoprotein, which forms disulfide-linked homodimers. It is expressed on activated T cells, as well as on granulocytes, monocytes, dendritic cells or mucosal T cells. It plays a major role in the activation of T cells by skin dendritic cells. Function of CD101 has not been fully elucidated, but in mice its knock-out results in liver autoimmune disease induced by Novosphingobium aromaticivorans.


The mouse monoclonal antibody BB27 recognizes CD101, a 140 kDa disulfide-bonded homodimeric protein expressed on activated T cells, and some ther cell types, such as granulocytes and cells of the monocyte/macropgage lineage.
HLDA V; WS Code T040

Regulatory Status


Human thymic clone B12

Species Reactivity:

  • Human

Negative Species:


  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry (frozen sections)
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).
  • Bagot M, Martinel I, Charue D, Weill F, Boulland ML, Wechsler J, Freeman GJ, Bensussan A, Boumsell L: CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation. Tissue Antigens. 1997 Nov;50(5):439-48. [Abstract]
  • *Bagot M, Martinel I, Charue D, Boulland ML, Wechsler J, Bensussan A, Boumsell L: Functional role of CD101 on skin dendritic cells. Adv Exp Med Biol. 1997;417:227-32. [Abstract]
  • *Grassi F, Dezutter-Dambuyant C, McIlroy D, Jacquet C, Yoneda K, Imamura S, Boumsell L, Schmitt D, Autran B, Debré P, Hosmalin A: Monocyte-derived dendritic cells have a phenotype comparable to that of dermal dendritic cells and display ultrastructural granules distinct from Birbeck granules. J Leukoc Biol. 1998 Oct;64(4):484-93. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    BB27 PE

    Fig. 1. Surface staining of human peripheral blood with anti-CD101 (BB27) PE.

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