System Certification ISO 9001:2000
Exbio Antibodies CZ / SK eShop
by categories | a-z list | Application type: Flow Cytometry | Immunohistochemistry | Functional Studies

Mouse Monoclonal to CD111 / Nectin-1

R1.302 (IgG1)

Technical Information Request    Inquiry for Bulk Prices

Product No. Form Quantity Stock Price Datasheet Shop
  11-780-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-780-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1P-780-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
  1P-780-T100 PE 100 tests yes choose region PDF datasheetHTML datasheet buy
- In stock! Ready for immediate despatch - Manufacture on order


CD111, also known as nectin-1, is a calcium-independent cell-cell adhesion transmembrane glycoprotein involved in organization of adherens junctions and tight junctions in epithelial and endothelial cells. It also serves as a target molecule for entry of herpes simplex virus (HSV-1, HSV-2) and pseudorabies virus (PRV) into epithelial and neuronal cells. CD111 is connected with actin cytoskeleton through afadin. Mutations in the gene for CD111 cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.


The mouse monoclonal antibody R1.302 recognizes CD111 (also known as Nectin 1), a 75 kDa type I transmembrane glycoprotein broadly expressed on endothelial cells, epithelial cells, neuronal cells, megakaryocytes, and CD34-positive stem cells.

Regulatory Status


NIH/3T3 cells transfected with human CD111

Species Reactivity:

  • Human

Negative Species:


  • Flow Cytometry
  • Immunoprecipitation
  • Western Blotting
  • Immunohistochemistry
  • Immunocytochemistry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

General references

  • *Cocchi F, Lopez M, Dubreuil P, Campadelli Fiume G, Menotti L: Chimeric nectin1-poliovirus receptor molecules identify a nectin1 region functional in herpes simplex virus entry. J Virol. 2001 Sep;75(17):7987-94. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    R1-302 pur

    Fig. 1. Surface staining of human peripheral blood with anti-human CD111 (R1.302) purified, GAM-APC.

    R1-302 PE

    Fig. 2. Surface staining of human peripheral blood with anti-human CD111 (R1.302) PE.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at
    © 2003 EXBIO. All rights reserved.
    terms and conditions | privacy policy