System Certification ISO 9001:2000
Exbio Antibodies CZ / SK eShop
by categories | a-z list | Application type: Flow Cytometry | Immunohistochemistry | Functional Studies

Mouse Monoclonal to Myeloperoxidase (MPO)

MPO421-8B2 (IgG1)

Technical Information Request    Inquiry for Bulk Prices

Product No. Form Quantity Stock Price Datasheet Shop
  11-791-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-791-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1F-791-T025 FITC 25 tests yes choose region PDF datasheetHTML datasheet buy
  1F-791-T100 FITC 100 tests yes choose region PDF datasheetHTML datasheet buy
  1P-791-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
  1P-791-T100 PE 100 tests yes choose region PDF datasheetHTML datasheet buy
- In stock! Ready for immediate despatch - Manufacture on order

Background

Myeloperoxidase (MPO) is a heme enzyme that is localized in azurophilic (primary) granules of myeloid cells and its synthesis occurs at an early stage of differentiation. The mature myeloperoxidase is a tetramer composed of two light (12 kDa) and two heavy (60 kDa) chains. This enzyme uses hydrogen peroxide to oxidize numerous substrates, including serotonin, melatonin or chloride, to produce reactive free radicals that contribute to immune reactions of myeloid cells against pathogens. Myeloperoxidase functions not only in host defense by mediating efficient microbial killing but also can contribute to progressive tissue damage in chronic inflammatory states such as atherosclerosis or acute pancreatitis.

Specificity

The mouse monoclonal antibody MPO421-8B2 recognizes human myeloperoxidase, a heme protein present in myeloblasts, neutrophils and monocytes. It is a marker of acute myelogenous leukemias and acute lymphoblastic leukemias.

Regulatory Status

Immunogen

Human myeloperoxidase

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
    Application note:intracellular staining
  • ELISA
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

References

  • Unpublished.
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    MPO421-8B2 FITC


    Fig. 1. Intracellular staining of human peripheral blood with anti-myeloperoxidase (MPO421-8B2) FITC.


    mpo421-8b2 pe


    Fig. 2. Intracellular staining of human peripheral blood with anti-myeloperoxidase (MPO421-8B2) PE.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
    © 2003 EXBIO. All rights reserved.
    terms and conditions | privacy policy