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Mouse Monoclonal to GARP / LRRC32

GARP5 (IgG1)

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  11-744-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
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Background

GARP (glycoprotein A repetitions predominant protein), also known as Garpin or LRRC32 (leucin-rich repeat containing protein 32) is an approximately 80 kDa transmembrane glycoprotein detected on the surface of megakaryocytes, platelets, and activated Treg cells. It binds to the latency-associated peptide (LAP) domain of pro-TGF beta and regulates its storage and activation. The expression of GARP on Treg cells seems to be necessary for their suppressive functions.

Specificity

The mouse monoclonal antibody GARP5 recognizes GARP / LRRC32, an approximately 80 kDa glycoprotein expressed e.g. on the surface of megakaryocytes, platelets and activated Treg cells.

Regulatory Status

Immunogen

Purified human sGARP protein

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Western Blotting
    Recommended dilution:1-2 μg/ml
    Positive control: human thrombocytes
    Application note: reducing conditions
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Wang R, Zhu J, Dong X, Shi M, Lu C, Springer TA: GARP regulates the bioavailability and activation of TGFβ. Mol Biol Cell. 2012 Mar;23(6):1129-39 [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    GARP
    Fig. 1



    Fig. 1.
    Western Blotting analysis (reducing conditions) of GARP antigen and its degradatory products in lysate of human thrombocytes by anti-GARP monoclonal antibody (GARP5).

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