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Mouse Monoclonal to CD56 / NCAM

LT56 (IgG2a)

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Background

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.

Specificity

The mouse monoclonal antibody LT56 recognizes CD56 (NCAM), a transmembrane glycoprotein expressed ubiquitously in the nervous system and found also on T cells and NK cells.
HLDA 10

Regulatory Status

Immunogen

Cell line KG1a

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Western Blotting
    Application note:non-reducing conditions
  • ELISA
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

References

  • Unpublished.
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    LT56 PerCP-Cy5-5


    Fig. 1. Surface staining of human peripheral blood with anti-human CD56 (LT56) PerCP-CyTM5.5.


    lt56


    Fig. 2. Surface staining of human peripheral blood with anti-human CD56 (LT56) PE.

    LT56 APC


    Fig. 3. Surface staining of human peripheral blood with anti-human CD56 (LT56) APC.


    LT56 PB


    Fig. 4. Surface staining of human peripheral blood with anti-human CD56 (LT56) Pacific BlueTM.


    LT56 PC7


    Fig. 5. Surface staining of human peripheral blood with anti-human CD56 (LT56) PE-CyTM7.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
    Alexa Fluor®, Pacific Blue™ and Pacific Orange™ are registred trademarks of Molecular Probes Inc., Eugene, OR, USA. (licence label)
    DyLight® is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
    Cy™ and CyDye™ are registered trademarks of GE Healthcare.
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