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Mouse Monoclonal to CD2

TS1/8 (IgG1)

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Background

CD2 (also known as LFA-2) belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.

Specificity

The mouse monoclonal antibody TS1/8 recognizes CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes.
HLDA V; WS Code S025

Regulatory Status

Immunogen

Cytotoxic T lymphocytes

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
  • Functional Application
    blocking
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).
  • Vollger LW, Tuck DT, Springer TA, Haynes BF, Singer KH: Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens. J Immunol. 1987 Jan 15;138(2):358-63. [Abstract]
  • *Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA: Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A. 1982 Dec;79(23):7489-93. [Abstract]
  • *Zhang B, Dai M, Li QJ, Zhuang Y: Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination. PLoS Genet. 2013 Oct;9(10):e1003887. [Abstract]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    TS1-8 PE-Cy7


    Fig. 1. Surface staining of CD2 in human peripheral blood with anti-CD2 (TS1/8) PE-CyTM7.


    TS1-8 APC-Cy7


    Fig. 2. Surface staining of CD2 in human peripheral blood with anti-CD2 (TS1/8) APC-CyTM7.


    TS1-8


    Fig. 3. Surface staining of CD2 in human peripheral blood with anti-CD2 (TS1/8) PE.

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