Mouse Monoclonal to DDIT4L
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(DNA-damage-inducible transcript 4-like), also known as REDD2 (regulated in development and DNA damage response 2) or RTP801L is a stress-inducted protein, which was shown to mediate monocyte cell death through a reduction in thioredoxin-1 expression, and is highly expressed in atherosclerotic lesions. Stimulation of DDIT4L expression in macrophages increases oxidized LDL-induced macrophage death.
The mouse monoclonal antibody DDIT-03 recognizes DDIT4L / REDD2 protein, which belongs to stress-induced proteins involved in mediation of cell death.
N-terminal recombinant fragment of human DDIT4L (amino acids 2-98)
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.
*Imen JS, Billiet L, Cuaz-Pérolin C, Michaud N, Rouis M: The regulated in development and DNA damage response 2 (REDD2) gene mediates human monocyte cell death through a reduction in thioredoxin-1 expression. Free Radic Biol Med. 2009 May 15;46(10):1404-10 [Abstract]
*Corradetti MN, Inoki K, Guan KL: The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005 Mar 18;280(11):9769-72. [Abstract] [Full Text]
*Cuaz-Pérolin C, Furman C, Larigauderie G, Legedz L, Lasselin C, Copin C, Jaye M, Searfoss G, Yu KT, Duverger N, Nègre-Salvayre A, Fruchart JC, Rouis M.REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1830-5. [Abstract] [Full Text]
For research use only. Not for drug, diagnostic or other use.
Western blotting analysis of DDIT4L expression in HEK293-DDIT4L transfectants and HEK293 cells using mouse monoclonal antibody DDIT-03