System Certification ISO 9001:2000
Exbio Antibodies CZ / SK eShop
by categories | a-z list | Application type: Flow Cytometry | Immunohistochemistry | Functional Studies

Mouse Monoclonal to DR3 / TRAMP

JD3 (IgG1)

Technical Information Request    Inquiry for Bulk Prices

Product No. Form Quantity Stock Price Datasheet Shop
  11-757-C025 purified 0.025 mg yes choose region PDF datasheetHTML datasheet buy
  11-757-C100 purified 0.1 mg yes choose region PDF datasheetHTML datasheet buy
  1P-757-T025 PE 25 tests yes choose region PDF datasheetHTML datasheet buy
  1P-757-T100 PE 100 tests yes choose region PDF datasheetHTML datasheet buy
- In stock! Ready for immediate despatch - Manufacture on order

Background

DR3, also known as APO-3, TRAMP or TNFRSF12, is a death domain-containing receptor of TNFR family, which is expressed preferentially in peripheral blood leukocytes and in the lymphocyte-enriched tissues. Its expression has been shown to be especially up-regulated in activated T cells. DR3 participates e.g. in the removal of self-reactive T cells in the thymus. The ligand for DR3 is TL1A (TNF-like ligand 1A), which is expressed in a variety of cell types (induced by inflammatory stimuli), and can also be released as a soluble factor. The TL1A/DR3 axis has been shown to costimulate T cells to produce a wide variety of cytokines and leads to T cell differentiation towards Th1 and Th17 types.

Specificity

The mouse monoclonal antibody JD3 recognizes DR3 (APO-3, TNFRSF12), a transmembrane protein of TNFR superfamily expressed mainly in lymphocyte-enriched tissues.

Regulatory Status

Immunogen

human DR3-Ig fusion protein

Species Reactivity:

  • Human

Negative Species:

Applications:

  • Flow Cytometry
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H: Multiple pathways of TWEAK-induced cell death. J Immunol. 2002 Jan 15;168(2):734-43. [Abstract]
  • *Cavallini C, Lovato O, Bertolaso A, Pacelli L, Zoratti E, Zanolin E, Krampera M, Zamò A, Tecchio C, Cassatella MA, Pizzolo G, Scupoli MT: The TNF-family cytokine TL1A inhibits proliferation of human activated B cells. PLoS One. 2013;8(4):e60136. [Abstract] [Full Text]
  • *Yi B, Zhang M, Schwartz-Albiez R, Cao Y: Mechanisms of the apoptosis induced by CD176 antibody in human leukemic cells. Int J Oncol. 2011 Jun;38(6):1565-73. [Abstract]
  • *Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA: Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J. 2011 Jan;25(1):409-19. [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data

    1P-757


    Fig. 1. Surface staining of DR3 on DR3-transfected and non-transfected Hek293 cells using mouse monoclonal antibody JD3 PE.

    Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO´s term and conditions which are available at www.exbio.cz.
    © 2003 EXBIO. All rights reserved.
    terms and conditions | privacy policy