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Rat Monoclonal to CD197 / CCR7 (mouse)

4B12 (IgG2a)

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CD197 / CCR7 (chemokine receptor 7) is a seven membrane-spanning protein serving as a receptor for chemokines CCL19 and CCL21. It is expressed on most naive T cells, some hematopoietic stem cells, mature dendritic cells, NK cells and some memory T cells and B cells subsets. CD197 plays important roles in development of thymocytes, and regulating the recirculation and homing of lymphocytes and dendritic cells to secondary lymphoid organs.


The rat monoclonal antibody 4B12 recognizes murine CD197 / CCR7 (chemokine receptor 7), a 43 kDa G-protein-coupled receptor for chemokines CCL19 and CCL21.

Regulatory Status


Murine CD197-transfected RBL-2H3 cells

Species Reactivity:

  • Mouse

Negative Species:


  • Flow Cytometry
  • Immunoprecipitation
Usage note:
Indicated dilutions are recommended starting points for use of this product. Working concentrations should be determined by the investigator.

Product Specific References

  • *Singh V, Gowthaman U, Jain S, Parihar P, Banskar S, Gupta P, Gupta UD, Agrewala JN: Coadministration of interleukins 7 and 15 with bacille Calmette-Guérin mounts enduring T cell memory response against Mycobacterium tuberculosis. J Infect Dis. 2010 Aug 15;202(3):480-9 [Abstract] [Full Text]
  • *Adachi K, Osada Y, Nakamura R, Tamada K, Hamano S: Unique T Cells with Unconventional Cytokine Profiles Induced in the Livers of Mice during Schistosoma mansoni Infection. PLoS One. 2013 Dec 16;8(12):e82698. [Abstract] [Full Text]
  • *Huggins A, Paschalidis N, Flower RJ, Perretti M, D'Acquisto F: Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation. FASEB J. 2009 Apr;23(4):985-96 [Abstract] [Full Text]
  • *Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2012 Apr 25;484(7395):510-3 [Abstract] [Full Text]
  • For research use only. Not for drug, diagnostic or other use.

    Example Data


    Fig. 1. Surface staining of murine splenocytes with anti-CD197 (4B12) PE.

    4b12 purified

    Fig. 2. Surface staining of murine splenocytes with anti-CD197 (4B12) purified, DAR-APC.

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